Department for Gynaecological and Breast Oncology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia.
Medical Faculty, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.
Curr Oncol. 2021 Aug 3;28(4):2928-2932. doi: 10.3390/curroncol28040256.
(1) Background. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions, characterized by extensive necrosis and detachment of the epidermis. (2) Case presentation. We present a case of a 46-year-old patient with late-stage high-grade serous ovarian cancer who was primarily treated with neoadjuvant chemotherapy and interval debulking, which was followed by adjuvant chemotherapy. At first recurrence, she was again treated with chemotherapy, and due to severe abdominal pain, an elastomeric pump containing analgesics, anti-inflammatories, and ondansetron was administered. In the same month, she was admitted to the hospital due to severe dysphagia, and in the following days she developed haemorrhagic vesiculobullous lesions on the facial skin and trunk. Stevens-Johnson syndrome was confirmed and ondansetron as a plausible leading cause was discontinued. Despite multimodal treatment, her condition deteriorated, and she died. (3) Discussion and conclusion. Although gynaecologists rarely encounter Stevens-Johnson syndrome, high mortality of the disease should ensure a low threshold for diagnosing and treating this disease.
(1) 背景：史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是严重的黏膜皮肤反应，其特征为广泛的表皮坏死和脱落。
(2) 病例介绍：我们报告了一例 46 岁晚期高级别浆液性卵巢癌患者的病例，该患者最初接受新辅助化疗和间隔减瘤术治疗，随后接受辅助化疗。第一次复发时，她再次接受化疗治疗，由于严重的腹痛，给予了含有镇痛药、消炎药和昂丹司琼的弹性泵。同月，她因严重的吞咽困难住院，随后几天在面部皮肤和躯干上出现了出血性水疱样病变。确诊为史蒂文斯-约翰逊综合征，并停用了昂丹司琼这一可能的主要致病药物。尽管采用了多模式治疗，但她的病情仍恶化，并最终死亡。
(3) 讨论和结论：尽管妇科医生很少遇到史蒂文斯-约翰逊综合征，但该病的高死亡率应确保对该病的诊断和治疗具有较低的门槛。
