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从 中提取的 Phlorofucofuroeckol A 和 Dieckol 对小鼠噪声性听力损失的影响。

Effect of Phlorofucofuroeckol A and Dieckol Extracted from on Noise-induced Hearing Loss in a Mouse Model.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 03080, Korea.

Interdisciplinary Program in Neuroscience, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.

出版信息

Mar Drugs. 2021 Aug 1;19(8):443. doi: 10.3390/md19080443.

DOI:10.3390/md19080443
PMID:34436282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8400186/
Abstract

One of the well-known causes of hearing loss is noise. Approximately 31.1% of Americans between the ages of 20 and 69 years (61.1 million people) have high-frequency hearing loss associated with noise exposure. In addition, recurrent noise exposure can accelerate age-related hearing loss. Phlorofucofuroeckol A (PFF-A) and dieckol, polyphenols extracted from the brown alga , are potent antioxidant agents. In this study, we investigated the effect of PFF-A and dieckol on the consequences of noise exposure in mice. In 1,1-diphenyl-2-picrylhydrazyl assay, dieckol and PFF-A both showed significant radical-scavenging activity. The mice were exposed to 115 dB SPL of noise one single time for 2 h. Auditory brainstem response(ABR) threshold shifts 4 h after 4 kHz noise exposure in mice that received dieckol were significantly lower than those in the saline with noise group. The high-PFF-A group showed a lower threshold shift at click and 16 kHz 1 day after noise exposure than the control group. The high-PFF-A group also showed higher hair cell survival than in the control at 3 days after exposure in the apical turn. These results suggest that noise-induced hair cell damage in cochlear and the ABR threshold shift can be alleviated by dieckol and PFF-A in the mouse. Derivatives of these compounds may be applied to individuals who are inevitably exposed to noise, contributing to the prevention of noise-induced hearing loss with a low probability of adverse effects.

摘要

噪声是导致听力损失的一个已知原因。大约 20 至 69 岁的美国人中有 31.1%（6110 万人）高频听力损失与噪声暴露有关。此外，反复的噪声暴露会加速与年龄相关的听力损失。来自褐藻的多酚化合物 phlorofucofuroeckol A（PFF-A）和 dieckol 是有效的抗氧化剂。在这项研究中，我们研究了 PFF-A 和 dieckol 对暴露于噪声的小鼠的影响。在 1,1-二苯基-2-苦基肼（1,1-diphenyl-2-picrylhydrazyl，DPPH）试验中，dieckol 和 PFF-A 均显示出显著的自由基清除活性。将小鼠单次暴露于 115 dB SPL 的噪声中 2 小时。在接受 dieckol 的小鼠中，4 kHz 噪声暴露 4 小时后，听觉脑干反应（auditory brainstem response，ABR）阈值的偏移明显低于盐水加噪声组。与对照组相比，高 PFF-A 组在噪声暴露后 1 天的 click 和 16 kHz 时的阈值偏移较低。在暴露后 3 天，高 PFF-A 组在外周区域的毛细胞存活率也高于对照组。这些结果表明，在小鼠中，噪声诱导的耳蜗毛细胞损伤和 ABR 阈值偏移可以被 dieckol 和 PFF-A 减轻。这些化合物的衍生物可应用于不可避免地暴露于噪声的个体，有助于预防噪声性听力损失，且不良反应的可能性较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/1ce85ee2a18b/marinedrugs-19-00443-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/1aadba3fb240/marinedrugs-19-00443-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/7590959cf9eb/marinedrugs-19-00443-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/0f758f1c8040/marinedrugs-19-00443-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/7691179c74c9/marinedrugs-19-00443-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/1ce85ee2a18b/marinedrugs-19-00443-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/1aadba3fb240/marinedrugs-19-00443-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/7590959cf9eb/marinedrugs-19-00443-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/0f758f1c8040/marinedrugs-19-00443-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/7691179c74c9/marinedrugs-19-00443-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4263/8400186/1ce85ee2a18b/marinedrugs-19-00443-g005.jpg

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