• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

铝-[F]氟化物的变革：简单放射化学对放射性标记生物分子产生重大影响

The aluminium-[F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules.

作者信息

Archibald Stephen J, Allott Louis

机构信息

Positron Emission Tomography Research Centre, Faculty of Health Sciences, University of Hull, Cottingham Road, Kingston upon Hull, HU6 7RX, UK.

Department of Biomedical Sciences, Faculty of Health Sciences, University of Hull, Cottingham Road, Kingston upon Hull, HU6 7RX, UK.

出版信息

EJNMMI Radiopharm Chem. 2021 Aug 26;6(1):30. doi: 10.1186/s41181-021-00141-0.

DOI:10.1186/s41181-021-00141-0
PMID:34436693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8390636/
Abstract

The aluminium-[F]fluoride ([F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.

摘要

铝-[F]氟化物（[F]AlF）放射性标记方法将氟-18良好的衰变特性与基于金属的放射化学的便利性和熟知性相结合，已被用于与镓-68放射性药物开发并行。因此，[F]AlF方法在临床放射性药物开发中很受欢迎且得到广泛应用。在本综述中，我们阐述了基于[F]AlF技术的现状，反思其对核医学的影响，并就这种独特的放射性标记方法的未来发展提出我们的看法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/042bbec2632f/41181_2021_141_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/a5ffc011bdf3/41181_2021_141_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/1c119cd8e09c/41181_2021_141_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/23c5c8de6ee3/41181_2021_141_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/d5260910031e/41181_2021_141_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/955b534c28de/41181_2021_141_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/4fbdfb084756/41181_2021_141_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/e21c9283770a/41181_2021_141_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/9d9bcc1a2c1a/41181_2021_141_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/3525f67afa6b/41181_2021_141_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/9f9120624d2a/41181_2021_141_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/042bbec2632f/41181_2021_141_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/a5ffc011bdf3/41181_2021_141_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/1c119cd8e09c/41181_2021_141_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/23c5c8de6ee3/41181_2021_141_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/d5260910031e/41181_2021_141_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/955b534c28de/41181_2021_141_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/4fbdfb084756/41181_2021_141_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/e21c9283770a/41181_2021_141_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/9d9bcc1a2c1a/41181_2021_141_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/3525f67afa6b/41181_2021_141_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/9f9120624d2a/41181_2021_141_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3249/8390636/042bbec2632f/41181_2021_141_Fig12_HTML.jpg

相似文献

1
The aluminium-[F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules.铝-[F]氟化物的变革：简单放射化学对放射性标记生物分子产生重大影响
EJNMMI Radiopharm Chem. 2021 Aug 26;6(1):30. doi: 10.1186/s41181-021-00141-0.
2
Correction to: The aluminium-[18F]fuoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules.对《铝-[18F]氟化物革命：用于放射性标记生物分子的具有重大影响的简单放射化学》的修正
EJNMMI Radiopharm Chem. 2021 Sep 24;6(1):32. doi: 10.1186/s41181-021-00148-7.
3
A kit-based aluminium-[F]fluoride approach to radiolabelled microbubbles.基于试剂盒的铝-[F]氟化物方法用于放射性标记微泡。
Chem Commun (Camb). 2021 Nov 4;57(88):11677-11680. doi: 10.1039/d1cc04790f.
4
Inorganic approaches for radiolabelling biomolecules with fluorine-18 for imaging with positron emission tomography.用氟-18 对生物分子进行放射性标记的无机方法，用于正电子发射断层扫描成像。
Dalton Trans. 2011 Jun 21;40(23):6196-205. doi: 10.1039/c0dt01594f. Epub 2011 Apr 15.
5
F-AlF Labeled Peptide and Protein Conjugates as Positron Emission Tomography Imaging Pharmaceuticals.F-AlF 标记的肽和蛋白质缀合物作为正电子发射断层扫描成像药物。
Bioconjug Chem. 2018 Apr 18;29(4):953-975. doi: 10.1021/acs.bioconjchem.7b00817. Epub 2018 Mar 9.
6
Three methods for 18F labeling of the HER2-binding affibody molecule Z(HER2:2891) including preclinical assessment.三种方法用于 18F 标记 HER2 结合亲和体分子 Z(HER2:2891)，包括临床前评估。
J Nucl Med. 2013 Nov;54(11):1981-8. doi: 10.2967/jnumed.113.122465. Epub 2013 Oct 10.
7
Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production.iMiDEV™ 的实现，一种用于放射性药物生产的全新全自动化微流控平台。
Lab Chip. 2021 Jun 1;21(11):2272-2282. doi: 10.1039/d1lc00148e.
8
Automated sulfur-[F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform.使用基于GE FASTlab™盒式平台对前列腺特异性膜抗原（PSMA）靶向配体进行自动化硫-[F]氟化物交换放射性标记。
React Chem Eng. 2023 Aug 21;8(10):2403-2407. doi: 10.1039/d3re00307h. eCollection 2023 Sep 26.
9
In Vitro and In Vivo Characterization of an F-AlF-Labeled PSMA Ligand for Imaging of PSMA-Expressing Xenografts.F-AlF 标记的 PSMA 配体的体外和体内特性分析用于 PSMA 表达异种移植的成像。
J Nucl Med. 2019 Jul;60(7):1017-1022. doi: 10.2967/jnumed.118.218941. Epub 2019 Jan 17.
10
Syntheses and preliminary evaluation of [(18) F]AlF-NOTA-G-TMTP1 for PET imaging of high aggressive hepatocellular carcinoma.用于高侵袭性肝细胞癌PET成像的[(18)F]AlF-NOTA-G-TMTP1的合成与初步评估
Contrast Media Mol Imaging. 2016 Jul;11(4):262-71. doi: 10.1002/cmmi.1688. Epub 2016 Mar 1.

引用本文的文献

1
Optimization of a GMP-compliant automated one-pot synthesis of Al[F]F-NOTA-Ubiquicidin for bacterial infection imaging by PET/CT.用于PET/CT细菌感染成像的符合GMP标准的Al[F]F-NOTA-泛喹杀菌素自动化一锅法合成的优化。
EJNMMI Radiopharm Chem. 2025 Jul 28;10(1):48. doi: 10.1186/s41181-025-00370-7.
2
Structure-activity relationship of F-labeled PD-L1-targeting small molecule ligands: impact of radiolabeling strategy on affinity and in vivo performance.F 标记的靶向 PD-L1 的小分子配体的构效关系：放射性标记策略对亲和力和体内性能的影响
EJNMMI Radiopharm Chem. 2025 Jul 1;10(1):33. doi: 10.1186/s41181-025-00359-2.
3

本文引用的文献

1
Radiolabeling Optimization and Preclinical Evaluation of the New PSMA Imaging Agent [F]AlF-P16-093.新型 PSMA 成像剂[F]AlF-P16-093 的放射性标记优化及临床前评价。
Bioconjug Chem. 2021 May 19;32(5):1017-1026. doi: 10.1021/acs.bioconjchem.1c00177. Epub 2021 Apr 19.
2
FAPI-04 PET/CT Using [F]AlF Labeling Strategy: Automatic Synthesis, Quality Control, and Assessment in Patient.采用[F]AlF标记策略的FAPI-04 PET/CT：自动合成、质量控制及患者评估
Front Oncol. 2021 Mar 19;11:649148. doi: 10.3389/fonc.2021.649148. eCollection 2021.
3
High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress.
Macrophage mannose receptor CD206-targeted PET imaging in experimental acute myocardial infarction.
实验性急性心肌梗死中巨噬细胞甘露糖受体CD206靶向正电子发射断层显像
EJNMMI Res. 2025 Jun 4;15(1):66. doi: 10.1186/s13550-025-01254-2.
4
Positron Emission Tomography Imaging of the Adaptive Immune System in Cardiovascular Diseases.心血管疾病中适应性免疫系统的正电子发射断层扫描成像
Chem Biomed Imaging. 2025 Mar 19;3(4):209-224. doi: 10.1021/cbmi.4c00117. eCollection 2025 Apr 28.
5
Optimizing antibody PET imaging: a comparative preclinical analysis of nanobody and minibody-like PET tracers.优化抗体正电子发射断层扫描成像：纳米抗体和类微型抗体正电子发射断层扫描示踪剂的比较临床前分析
Eur J Nucl Med Mol Imaging. 2025 Mar 31. doi: 10.1007/s00259-025-07205-2.
6
Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [F]MeTz-PEG-RM26 for positron emission tomography.用于正电子发射断层扫描的胃泌素释放肽受体拮抗剂[F]MeTz-PEG-RM26的合成与临床前评价
EJNMMI Radiopharm Chem. 2025 Mar 26;10(1):14. doi: 10.1186/s41181-025-00336-9.
7
On the automated radiosynthesis of pharmaceutical grade [Ga]Ga-Pentixafor, its pre-clinical evaluation, clinical application and radiation dosimetry aspects.关于药用级[镓]镓喷替沙福的自动化放射性合成、临床前评估、临床应用及辐射剂量学方面。
Sci Rep. 2025 Feb 22;15(1):6476. doi: 10.1038/s41598-024-84096-7.
8
Evaluation of [F]AlF NOTA-5G, an Aluminum [F]fluoride Labeled Peptide Targeting the Cell Surface Receptor Integrin Alpha(v)beta(6) for PET Imaging.用于正电子发射断层显像（PET）成像的靶向细胞表面受体整合素α(v)β(6)的铝[F]氟化物标记肽[F]AlF NOTA-5G的评估。
Mol Imaging Biol. 2025 Apr;27(2):285-292. doi: 10.1007/s11307-025-01989-3. Epub 2025 Feb 20.
9
Simple and Efficient Synthesis of -Succinimidyl-4-[F]fluorobenzoate ([F]SFB)-An Important Intermediate for the Introduction of Fluorine-18 into Complex Bioactive Compounds.-琥珀酰亚胺基-4-[¹⁸F]氟苯甲酸酯（[¹⁸F]SFB）的简便高效合成——将氟-18引入复杂生物活性化合物的重要中间体
Pharmaceuticals (Basel). 2024 Dec 20;17(12):1723. doi: 10.3390/ph17121723.
10
Bifunctional Hexadentate Pyclen-Based Chelating Agent for Mild Radiofluorination in Aqueous Solution at Room Temperature with a Ga-F Ternary Complex.用于室温下在水溶液中通过镓-氟三元络合物进行温和放射性氟化的基于双功能六齿Pyclen的螯合剂。
Chemistry. 2024 Dec 5;30(68):e202403358. doi: 10.1002/chem.202403358. Epub 2024 Nov 9.
通过液滴放射化学实现放射性药物的高效生产：近期进展综述。
Mol Imaging. 2020 Jan-Dec;19:1536012120973099. doi: 10.1177/1536012120973099.
4
Intra-individual dynamic comparison of F-PSMA-11 and Ga-PSMA-11 in LNCaP xenograft bearing mice.在 LNCaP 异种移植瘤荷瘤小鼠中进行 F-PSMA-11 和 Ga-PSMA-11 的个体内动态比较。
Sci Rep. 2020 Dec 3;10(1):21068. doi: 10.1038/s41598-020-78273-7.
5
Cyclotron-based production of Ga, [Ga]GaCl, and [Ga]Ga-PSMA-11 from a liquid target.基于回旋加速器从液体靶材生产镓、[镓]氯化镓和[镓]镓-PSMA-11 。
EJNMMI Radiopharm Chem. 2020 Nov 12;5(1):25. doi: 10.1186/s41181-020-00106-9.
6
Automated [F]PSMA-1007 production by a single use cassette-type synthesizer for clinical examination.用于临床检查的一次性盒式合成器自动生产[F]PSMA - 1007
EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):18. doi: 10.1186/s41181-020-00101-0.
7
Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes.GrB PET 显像在免疫检查点抑制剂联合治疗结直肠癌表型中的应用。
Mol Imaging Biol. 2020 Oct;22(5):1392-1402. doi: 10.1007/s11307-020-01519-3.
8
High-Yielding Radiosynthesis of [Ga]Ga-PSMA-11 Using a Low-Cost Microfluidic Device.使用低成本微流控装置高产率合成 [Ga]Ga-PSMA-11。
Mol Imaging Biol. 2020 Oct;22(5):1370-1379. doi: 10.1007/s11307-020-01515-7.
9
[F]AlF-NOTA-octreotide PET imaging: biodistribution, dosimetry and first comparison with [Ga]Ga-DOTATATE in neuroendocrine tumour patients.[F]AlF-NOTA-奥曲肽正电子发射断层显像：神经内分泌肿瘤患者的生物分布、剂量测定及与[Ga]Ga- DOTATATE的首次比较
Eur J Nucl Med Mol Imaging. 2020 Dec;47(13):3033-3046. doi: 10.1007/s00259-020-04918-4. Epub 2020 Jul 2.
10
FAPI-74 PET/CT Using Either F-AlF or Cold-Kit Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients.使用 F-AlF 或冷试剂盒 Ga 标记的 FAPI-74 PET/CT：肺癌患者的生物分布、辐射剂量学和肿瘤勾画。
J Nucl Med. 2021 Feb;62(2):201-207. doi: 10.2967/jnumed.120.245084. Epub 2020 Jun 26.