• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基因与注意/多动问题关联的大脑解剖学中介：一项综合遗传-神经影像学研究。

Brain Anatomical Mediators of Gene Association with Attention/Hyperactivity Problems: An Integrated Genetic-Neuroimaging Study.

机构信息

Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 22040 Bosisio Parini, Italy.

Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

出版信息

Genes (Basel). 2021 Jul 30;12(8):1193. doi: 10.3390/genes12081193.

DOI:10.3390/genes12081193
PMID:34440367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8394308/
Abstract

This study aims to investigate the genetic and neural determinants of attention and hyperactivity problems. Using a proof-of-concept imaging genetics mediation design, we explore the relationship between the glutamatergic gene variants and inattention/hyperactivity with neuroanatomical measures as intermediates. Fifty-eight children and adolescents were evaluated for behavioral problems at three time points over approximately 7 years. The final assessment included blood drawing for genetic analyses and 3T magnetic resonance imaging. Attention/hyperactivity problems based on the Child Behavior Checklist/6-18, six polymorphisms and regional cortical thickness, and surface area and volume were estimated. Using general linear model (GLM) and mediation analyses, we tested whether exerted an influence on stable inattention/hyperactivity over development, and to what extent this effect was mediated by brain morphology. GLM results enlightened the relation between rs5796555-/A, volume in the left cingulate isthmus and inferior parietal cortices and inattention/hyperactivity. The mediation results showed that rs5796555-/A effect on inattention/hyperactivity was partially mediated by volume in the left isthmus of the cingulate cortex, suggesting a key role of this region in translating glutamatergic variations to attention/hyperactivity problems. This evidence can have important implications in the management of neurodevelopmental and psychiatric disorders.

摘要

本研究旨在探究注意力和多动问题的遗传和神经决定因素。采用概念验证成像遗传学中介设计，我们探讨了谷氨酸能基因变异与注意力不集中/多动之间的关系，以及神经解剖学指标作为中介。58 名儿童和青少年在大约 7 年内的三个时间点接受了行为问题评估。最终评估包括基因分析的采血和 3T 磁共振成像。根据儿童行为检查表/6-18 评估注意力/多动问题，对六个多态性和皮质区域厚度、表面积和体积进行了估计。使用一般线性模型 (GLM) 和中介分析，我们检验了 rs5796555-/A 是否对发展过程中的稳定注意力不集中/多动有影响，以及这种影响在多大程度上由大脑形态学介导。GLM 结果揭示了 rs5796555-/A 与左扣带回峡部和下顶叶皮质体积之间的关系与注意力不集中/多动有关。中介结果表明，rs5796555-/A 对注意力不集中/多动的影响部分由扣带回峡部左侧的体积介导，表明该区域在将谷氨酸能变异转化为注意力/多动问题方面起着关键作用。这一证据在神经发育和精神障碍的管理中具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ed/8394308/f29e620aff0f/genes-12-01193-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ed/8394308/24104c362bbc/genes-12-01193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ed/8394308/3b6fa95ccf11/genes-12-01193-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ed/8394308/f29e620aff0f/genes-12-01193-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ed/8394308/24104c362bbc/genes-12-01193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ed/8394308/3b6fa95ccf11/genes-12-01193-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ed/8394308/f29e620aff0f/genes-12-01193-g003.jpg

相似文献

1
Brain Anatomical Mediators of Gene Association with Attention/Hyperactivity Problems: An Integrated Genetic-Neuroimaging Study.基因与注意/多动问题关联的大脑解剖学中介：一项综合遗传-神经影像学研究。
Genes (Basel). 2021 Jul 30;12(8):1193. doi: 10.3390/genes12081193.
2
The effects of GRIN2B and DRD4 gene variants on local functional connectivity in attention-deficit/hyperactivity disorder.GRIN2B 和 DRD4 基因变异对注意缺陷多动障碍局部功能连接的影响。
Brain Imaging Behav. 2018 Feb;12(1):247-257. doi: 10.1007/s11682-017-9690-2.
3
Association of the GRIN2B rs2284411 polymorphism with methylphenidate response in attention-deficit/hyperactivity disorder.注意力缺陷多动障碍中GRIN2B基因rs2284411多态性与哌甲酯反应的关联
J Psychopharmacol. 2017 Aug;31(8):1070-1077. doi: 10.1177/0269881116667707. Epub 2016 Sep 13.
4
Cortical thickness and inattention/hyperactivity symptoms in young children: a population-based study.皮质厚度与幼儿注意力不集中/多动症状：一项基于人群的研究。
Psychol Med. 2014 Nov;44(15):3203-13. doi: 10.1017/S0033291714000877. Epub 2014 Jul 17.
5
GRIN2B predicts attention problems among disadvantaged children.GRIN2B 可预测弱势儿童的注意问题。
Eur Child Adolesc Psychiatry. 2015 Jul;24(7):827-36. doi: 10.1007/s00787-014-0627-7. Epub 2014 Oct 16.
6
Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder.患有注意力缺陷多动障碍的儿童和青少年的皮质异常。
Lancet. 2003 Nov 22;362(9397):1699-707. doi: 10.1016/S0140-6736(03)14842-8.
7
Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population.常见精神障碍和认知的多基因变异与一般儿科人群的大脑形态学的关系。
J Am Acad Child Adolesc Psychiatry. 2019 Jun;58(6):600-607. doi: 10.1016/j.jaac.2018.09.443. Epub 2019 Jan 9.
8
Cortical morphometry in attention deficit/hyperactivity disorder: Contribution of thickness and surface area to volume.注意缺陷多动障碍的皮质形态测量学：厚度和表面积对体积的贡献。
Cortex. 2016 Sep;82:1-10. doi: 10.1016/j.cortex.2016.05.012. Epub 2016 May 21.
9
Normal variation in behavioral adjustment relates to regional differences in cortical thickness in children.儿童行为调节的正常变异与皮质厚度的区域差异有关。
Eur Child Adolesc Psychiatry. 2012 Mar;21(3):133-40. doi: 10.1007/s00787-012-0241-5. Epub 2012 Feb 1.
10
Neonatal cerebral morphometry and later risk of persistent inattention/hyperactivity in children born very preterm.极低出生体重儿的新生儿脑形态测量与儿童期持续注意力不集中/多动的后期风险
J Child Psychol Psychiatry. 2014 Jul;55(7):828-38. doi: 10.1111/jcpp.12200. Epub 2014 Jan 20.

引用本文的文献

1
Internalizing and Externalizing Traits During Adolescence: Using Epigenetics and Perinatal Risks to Differentiate Clusters of Symptoms.青少年期的内化与外化特质：利用表观遗传学和围产期风险区分症状群
Biomolecules. 2025 Aug 7;15(8):1142. doi: 10.3390/biom15081142.
2
EEG Biomarkers for Autism: Rational, Support, and the Qualification Process.脑电图生物标志物在自闭症中的应用：原理、依据和资格认证流程。
Adv Neurobiol. 2024;40:545-576. doi: 10.1007/978-3-031-69491-2_19.
3
Right frontal cingulate cortex mediates the effect of prenatal complications on youth internalizing behaviors.

本文引用的文献

1
Associations Between Daily Mood States and Brain Gray Matter Volume, Resting-State Functional Connectivity and Task-Based Activity in Healthy Adults.健康成年人日常情绪状态与脑灰质体积、静息态功能连接及基于任务的活动之间的关联
Front Hum Neurosci. 2018 May 1;12:168. doi: 10.3389/fnhum.2018.00168. eCollection 2018.
2
Invariance of ADHD Symptoms Across Sex and Age: a Latent Analysis of ADHD and Impairment Ratings from Early Childhood into Adolescence.注意力缺陷多动障碍症状在性别和年龄上的不变性：从儿童早期到青少年时期注意力缺陷多动障碍和损害评定的潜在分析。
J Abnorm Child Psychol. 2019 Jan;47(1):21-34. doi: 10.1007/s10802-018-0434-6.
3
右侧额前扣带回皮层介导了产前并发症对青少年内化行为的影响。
Mol Psychiatry. 2024 Jul;29(7):2074-2083. doi: 10.1038/s41380-024-02475-y. Epub 2024 Feb 20.
4
Characterizing Sensory Phenotypes of Subgroups with a Known Genetic Etiology Pertaining to Diagnoses of Autism Spectrum Disorder and Intellectual Disability.表征具有已知遗传病因的自闭症谱系障碍和智力残疾诊断相关亚组的感觉表型。
J Autism Dev Disord. 2024 Jun;54(6):2386-2401. doi: 10.1007/s10803-023-05897-9. Epub 2023 Apr 8.
The effects of GRIN2B and DRD4 gene variants on local functional connectivity in attention-deficit/hyperactivity disorder.
GRIN2B 和 DRD4 基因变异对注意缺陷多动障碍局部功能连接的影响。
Brain Imaging Behav. 2018 Feb;12(1):247-257. doi: 10.1007/s11682-017-9690-2.
4
Latent classes of emotional and behavioural problems in epidemiological and referred samples and their relations to DSM-IV diagnoses.流行病学样本和转诊样本中情绪与行为问题的潜在类别及其与《精神疾病诊断与统计手册》第四版诊断的关系。
Eur Child Adolesc Psychiatry. 2017 May;26(5):549-557. doi: 10.1007/s00787-016-0918-2. Epub 2016 Nov 14.
5
Human GRIN2B variants in neurodevelopmental disorders.神经发育障碍中的人类GRIN2B基因变异体。
J Pharmacol Sci. 2016 Oct;132(2):115-121. doi: 10.1016/j.jphs.2016.10.002. Epub 2016 Oct 19.
6
Genetic variation within GRIN2B in adolescents with alcohol use disorder may be associated with larger left posterior cingulate cortex volume.GRIN2B 基因内的遗传变异可能与青少年酒精使用障碍患者左后扣带回皮质体积较大有关。
Acta Neuropsychiatr. 2017 Aug;29(4):252-258. doi: 10.1017/neu.2016.41. Epub 2016 Aug 8.
7
Structural and Functional Brain Abnormalities in Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder: A Comparative Meta-analysis.注意缺陷多动障碍与强迫症的大脑结构和功能异常：比较性元分析。
JAMA Psychiatry. 2016 Aug 1;73(8):815-825. doi: 10.1001/jamapsychiatry.2016.0700.
8
The and Gene Variants Are Associated With Continuous Performance Test Variables in ADHD.与 ADHD 连续表现测试变量相关的 和 基因变异。
J Atten Disord. 2020 Sep;24(11):1538-1546. doi: 10.1177/1087054716649665. Epub 2016 May 19.
9
Association of Parkinson disease age of onset with DRD2, DRD3 and GRIN2B polymorphisms.帕金森病发病年龄与DRD2、DRD3和GRIN2B基因多态性的关联。
Parkinsonism Relat Disord. 2016 Jan;22:102-5. doi: 10.1016/j.parkreldis.2015.11.016. Epub 2015 Nov 25.
10
Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo.突触前NMDA受体——体外和体内发育轴突中的动力学与分布
J Cell Sci. 2015 Feb 15;128(4):768-80. doi: 10.1242/jcs.162362. Epub 2014 Dec 19.