Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Neuroscience Institute, National Research Council (CNR), 35131 Padua, Italy.
Cells. 2021 Aug 19;10(8):2133. doi: 10.3390/cells10082133.
Calcium (Ca) signaling coordinates are crucial processes in brain physiology. Particularly, fundamental aspects of neuronal function such as synaptic transmission and neuronal plasticity are regulated by Ca, and neuronal survival itself relies on Ca-dependent cascades. Indeed, impaired Ca homeostasis has been reported in aging as well as in the onset and progression of neurodegeneration. Understanding the physiology of brain function and the key processes leading to its derangement is a core challenge for neuroscience. In this context, Ca imaging represents a powerful tool, effectively fostered by the continuous amelioration of Ca sensors in parallel with the improvement of imaging instrumentation. In this review, we explore the potentiality of the most used animal models employed for Ca imaging, highlighting their application in brain research to explore the pathogenesis of neurodegenerative diseases.
钙（Ca）信号协调是大脑生理学的关键过程。特别是，神经元功能的基本方面，如突触传递和神经元可塑性，受到 Ca 的调节，而神经元的存活本身依赖于 Ca 依赖性级联反应。事实上，在衰老以及神经退行性变的发生和进展中，已经报道了 Ca 动态平衡的受损。了解大脑功能的生理学以及导致其紊乱的关键过程是神经科学的核心挑战。在这种情况下，Ca 成像代表了一种强大的工具，这得益于 Ca 传感器的不断改进，同时也得益于成像仪器的改进。在这篇综述中，我们探讨了最常用于 Ca 成像的动物模型的潜力，强调了它们在脑研究中的应用，以探索神经退行性疾病的发病机制。
