Peper A, Grimbergen C A, Kraal J W, Engelbart J H
Laboratory of Medical Physics, University of Amsterdam, The Netherlands.
J Theor Biol. 1987 Aug 21;127(4):413-26. doi: 10.1016/s0022-5193(87)80139-x.
In this paper the disturbing effect of drugs upon regulation in the organism is argued to be an important factor in the total drug effect. It is made plausible that the decrease of the drug effect after prolonged or repeated administration of the drug is caused by the adaptation of the involved regulations to the presence of the drug, the adaptive process being selective for the drug in question. A model based on these assumptions is developed taking into account the specific behaviour of regulated processes. The functioning of the model is investigated by means of computer simulations. The behaviour of the model appears to be well in accordance with the phenomenon of drug tolerance as described in literature.
本文认为药物对机体调节的干扰作用是药物总体效应的一个重要因素。长期或重复给药后药物效应降低是由于相关调节机制对药物存在产生适应所致，这一点似乎是合理的，这种适应过程对所讨论的药物具有选择性。基于这些假设开发了一个模型，同时考虑了调节过程的特定行为。通过计算机模拟研究了该模型的功能。该模型的行为似乎与文献中描述的药物耐受性现象非常吻合。
