Modi N B, Veng-Pedersen P
University of Iowa, College of Pharmacy, Iowa City 52242.
Pharm Res. 1994 Jan;11(1):128-35. doi: 10.1023/a:1018966232183.
An important goal in therapeutics is the quantitative prediction of drug effects. Although several comprehensive pharmacodynamic models have been proposed, relatively few of these have attempted to assess objectively the application of the models to predict pharmacologic responses. A variable-direction hysteresis minimization approach was proposed recently that allowed the pharmacodynamics of drugs to be modeled using information about drug input. The application and validation of this approach are demonstrated using the pharmacodynamic effect of alfentanil, a short-acting narcotic analgesic agent, in New Zealand White rabbits. A parameter is proposed to assess the ability of the pharmacodynamic model to predict responses.
治疗学的一个重要目标是对药物效应进行定量预测。尽管已经提出了几种全面的药效学模型，但其中相对较少的模型试图客观地评估这些模型在预测药理反应方面的应用。最近提出了一种可变方向滞后最小化方法，该方法允许利用药物输入信息对药物的药效学进行建模。本文利用短效麻醉镇痛药阿芬太尼对新西兰白兔的药效学效应，展示了该方法的应用和验证。提出了一个参数来评估药效学模型预测反应的能力。
