assignment of absolute configurations of two promising anti- agents from the marine sponge- derived fungus l14.

Assignment of Absolute Configurations of Two Promising Anti- Agents from the Marine Sponge-Derived Fungus L14.

机构信息

School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology, Nanjing Medical University, Nanjing 211166, China.

出版信息

Molecules. 2021 Aug 20;26(16):5061. doi: 10.3390/molecules26165061.

DOI:10.3390/molecules26165061

PMID:34443650

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8399357/

Abstract

A chemical investigation into endozoic fungus L14 derived from the marine sponge of collected off Xinghai Bay (China) resulted in the isolation of two dimeric naphtho--pyrones, fonsecinone A () and isoaurasperone A (). Through a combination of ECD spectra and X-ray diffraction analysis, the chiral axes of compounds and were unambiguously determined as -configurations. Bioassay results indicated that these substances exhibited remarkably inhibitory effects on human pathogens G27 and 159 with MIC values of ≤4 μg/mL, which are similar to those of the positive control, ampicillin sodium. To the best of our knowledge, this is the first report on absolute configuration of and crystallographic data of , as well as their potent anti- activities.

摘要

从中国星海湾采集的海洋海绵内生真菌 L14 进行的化学研究导致分离出两种二聚萘并-吡喃酮，fonsecinone A()和 isoaurasperone A()。通过ECD 光谱和 X 射线衍射分析的组合，化合物和的手性轴被明确确定为 -构型。生物测定结果表明，这些物质对人类病原体 G27 和 159 表现出显著的抑制作用，MIC 值均≤4 μg/mL，与阳性对照氨苄西林钠相似。据我们所知，这是关于和的绝对构型以及它们的晶体学数据和强大的抗活性的首次报道。