Martin P, Massol J, Belon J P, Gaudel G, Soubrié P
Département de Pharmacologie, INSERM U 302, Paris, France.
Neuropsychobiology. 1987;18(1):21-6. doi: 10.1159/000118388.
Several investigations have suggested that a special relationship exists between thyroid function and affective disorders and/or therapeutic response to antidepressants. The present study shows that the reversal by clomipramine, desipramine, imipramine and nialamide of depressive-like behavior in rats (escape deficits produced by previous exposure to uncontrollable stress) was markedly attenuated in hypothyroid rats (propylthiouracil, 0.05% in the drinking water). Conversely, the effect of these same antidepressants was significantly hastened in euthyroid rats given daily triiodothyronine. This supports the notion of intricate thyroid/CNS interactions in the mechanisms of action of antidepressant drugs.
多项研究表明，甲状腺功能与情感障碍和/或抗抑郁药的治疗反应之间存在特殊关系。本研究表明，氯米帕明、地昔帕明、丙咪嗪和尼亚酰胺对大鼠抑郁样行为（先前暴露于不可控应激所产生的逃避缺陷）的逆转作用在甲状腺功能减退大鼠（饮用水中含0.05%丙硫氧嘧啶）中明显减弱。相反，在每天给予三碘甲状腺原氨酸的甲状腺功能正常大鼠中，这些抗抑郁药的作用显著加快。这支持了抗抑郁药作用机制中甲状腺/中枢神经系统存在复杂相互作用的观点。
