三碘甲状腺原氨酸增强抗抑郁药诱导的大鼠习得性无助逆转作用。

Triiodothyronine potentiation of antidepressant-induced reversal of learned helplessness in rats.

作者信息

Brochet D M, Martin P, Soubrié P, Simon P

出版信息

Psychiatry Res. 1987 Jul;21(3):267-75. doi: 10.1016/0165-1781(87)90031-x.

Abstract

Several clinical investigations have suggested that a special relationship exists between thyroid function and affective disorders and/or therapeutic response to antidepressants. The present report describes that the reversal by antidepressants (imipramine, desipramine, and nomifensine) of depressive-like behavior in rats (escape deficits produced by previous exposure to uncontrollable stress) was significantly hastened in animals given daily triiodothyronine (T3). The learned helplessness paradigm might be a useful model for approaching in animals the neurohormonal correlates of affective disorders and the neurobiochemical bases of the reported T3 enhancement of antidepressants.

摘要

多项临床研究表明，甲状腺功能与情感障碍和/或对抗抑郁药的治疗反应之间存在特殊关系。本报告描述了在每日给予三碘甲状腺原氨酸（T3）的动物中，抗抑郁药（丙咪嗪、地昔帕明和诺米芬辛）对大鼠抑郁样行为（先前暴露于不可控应激所产生的逃避缺陷）的逆转作用显著加快。习得性无助范式可能是一种有用的模型，可用于在动物中探讨情感障碍的神经激素相关性以及所报道的T3增强抗抑郁药作用的神经生化基础。