Madhukumar Meenu, Geetha Praveena, Nair K Radhakrishnan, Unnikrishnan Manu
Department of Conservative Dentistry and Endodontics, Azeezia College of Dental Science and Research, Kollam, Kerala, India.
Department of Conservative Dentistry and Endodontics, Chettinad Dental College and Research Institute, Kanchipuram, Tamil Nadu, India.
J Pharm Bioallied Sci. 2021 Jun;13(Suppl 1):S510-S515. doi: 10.4103/jpbs.JPBS_531_20. Epub 2021 Jun 5.
Double antibiotic paste is a root canal medicament used in regenerative endodontics and its long-term exposure to dental hard tissues was shown to reduce its mechanical properties. The amoxicillin-clavulanate paste is a medicament effective against endodontic pathogens and is effective in endodontic regeneration. Its effect on radicular dentine is yet to be investigated. The purpose of this study is to investigate and compare the effects of double antibiotic paste and amoxicillin-clavulanate paste on the microhardness of radicular dentine.
The root canal of 45 premolars was mechanically prepared and divided into three groups for the placement of intracanal medicament: Group 1 ( = 15) double antibiotic paste, Group 2 ( = 15) amoxicillin-clavulanate paste, and Group 3 control group ( = 15). All the specimens were subject to microhardness testing at 500 and 1000 microns depth for 1 week, 1 month, and 3 months and analyzed.
There is no significant reduction in microhardness of radicular dentin at 1 week on all the three groups. At 1 month and 3 month period, the amoxicillin-clavulanate paste is found to have no significant effect on dentin microhardness when compared to double antibiotic paste.
The use of amoxicillin-clavulanate paste as an intracanal medicament does not cause significant weakening of dentin even after its long-term use.
双抗生素糊剂是一种用于牙髓再生治疗的根管药物，研究表明其长期接触牙齿硬组织会降低其机械性能。阿莫西林 - 克拉维酸糊剂是一种对牙髓病原体有效的药物，对牙髓再生也有效。其对牙根牙本质的影响尚待研究。本研究的目的是调查和比较双抗生素糊剂和阿莫西林 - 克拉维酸糊剂对牙根牙本质显微硬度的影响。
对45颗前磨牙的根管进行机械预备，并分为三组用于根管内药物放置：第1组（n = 15）双抗生素糊剂，第2组（n = 15）阿莫西林 - 克拉维酸糊剂，第3组为对照组（n = 15）。所有标本在500和1000微米深度处进行1周、1个月和3个月的显微硬度测试并分析。
所有三组在1周时牙根牙本质的显微硬度均无显著降低。在1个月和3个月时，与双抗生素糊剂相比，发现阿莫西林 - 克拉维酸糊剂对牙本质显微硬度没有显著影响。
即使长期使用，将阿莫西林 - 克拉维酸糊剂用作根管内药物也不会导致牙本质显著弱化。
