Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, People's Republic of China.
Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, 210046, People's Republic of China.
Drug Des Devel Ther. 2021 Aug 20;15:3619-3641. doi: 10.2147/DDDT.S310686. eCollection 2021.
Icariin is a biologically active substance in that is used for the treatment of neurologic disorders. However, a comprehensive analysis of the molecular mechanisms of icariin is lacking. In this review, we present a brief history of the use of icariin for medicinal purposes; describe the active chemical components of ; and examine the evidence from experimental studies that have uncovered molecular targets of icariin in different diseases. We also constructed a protein-protein interaction network and carried out Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analyses to predict the therapeutic actions of icariin in nervous system diseases including Alzheimer disease, Parkinson disease, ischemic stroke, depressive disorder, multiple sclerosis, glioblastoma, and hereditary spastic paraplegias. The results of our analyses can guide future studies on the application of icariin to the treatment of neurologic disorders.
淫羊藿苷是 中的一种生物活性物质，用于治疗神经紊乱。然而，淫羊藿苷的分子机制仍缺乏全面分析。在这篇综述中，我们简要介绍了淫羊藿苷在药用方面的应用历史；描述了 中的活性化学成分；并研究了实验研究中揭示淫羊藿苷在不同疾病中分子靶点的证据。我们还构建了一个蛋白质-蛋白质相互作用网络，并进行了基因本体论和京都基因与基因组百科全书功能富集分析，以预测淫羊藿苷在包括阿尔茨海默病、帕金森病、缺血性中风、抑郁症、多发性硬化症、胶质母细胞瘤和遗传性痉挛性截瘫在内的神经系统疾病中的治疗作用。我们分析的结果可以指导未来将淫羊藿苷应用于治疗神经紊乱的研究。
