Diabetes, Endocrinology & Metabolism Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Curr Diab Rep. 2021 Aug 26;21(9):29. doi: 10.1007/s11892-021-01400-9.
Type 1 diabetes mellitus (T1DM) is associated with increased mortality, with premature cardiovascular disease (CVD) a major factor. To date, research has identified multiple risk factors for this excess CVD liability. However, gaps remain in our understanding of the underlying mechanisms.
T1DM is generally diagnosed at a young age. Since cardiovascular complications often only manifest at a later stage of life, there is generally less focus in earlier years on reducing CVD risk for affected individuals. This is an area that requires improvement as risk factors might be managed from earlier age to reduce later development of CVD. In this review, we discuss the evidence for cardiovascular risk factors, risk prediction models, candidate surrogate measurements and CVD risk management.
1 型糖尿病(T1DM)与死亡率增加有关,其中过早发生心血管疾病(CVD)是一个主要因素。迄今为止,研究已经确定了这种 CVD 负担增加的多个危险因素。然而,我们对潜在机制的理解仍存在差距。
T1DM 通常在年轻时被诊断出来。由于心血管并发症通常只在生命的后期才显现出来,因此在早期,人们通常较少关注减少受影响个体的 CVD 风险。这是一个需要改进的领域,因为可以从更早的年龄开始管理危险因素,以减少 CVD 的后期发展。在这篇综述中,我们讨论了心血管危险因素、风险预测模型、候选替代测量和 CVD 风险管理的证据。