Department of Ultrasonography, China-Japan Union Hospital of Jilin University, Changchun, 130003, People's Republic of China.
Department of Ambulatory Ward, China-Japan Union Hospital of Jilin University, Changchun, 130003, People's Republic of China.
Tissue Eng Regen Med. 2021 Oct;18(5):747-758. doi: 10.1007/s13770-021-00366-9. Epub 2021 Aug 27.
Endothelial progenitor cells (EPCs) are immature endothelial cells that participate in vascular repair and postnatal neovascularization and provide a novel and promising therapy for the treatment of vascular disease. Studies in different animal models have shown that EPC mobilization through pharmacological agents and autologous EPC transplantation contribute to restoring blood supply and tissue regeneration after ischemic injury. However, these effects of the progenitor cells in clinical studies exhibit mixed results. The therapeutic efficacy of EPCs is closely associated with the number of the progenitor cells recruited into ischemic regions and their functional abilities and survival in injury tissues. In this review, we discussed the regulating role of stromal cell-derived factor-1 (also known CXCL12, SDF-1) in EPC mobilization, recruitment, homing, vascular repair and neovascularization, and analyzed the underlying machemisms of these functions. Application of SDF-1 to improve the regenerative function of EPCs following vascular injury was also discussed. SDF-1 plays a crucial role in mobilizing EPC from bone marrow into peripheral circulation, recruiting the progenitor cells to target tissue and protecting against cell death under pathological conditions; thus improve EPC regenerative capacity. SDF-1 are crucial for regulating EPC regenerative function, and provide a potential target for improve therapeutic efficacy of the progenitor cells in treatment of vascular disease.
内皮祖细胞（EPCs）是不成熟的内皮细胞，参与血管修复和出生后新生血管形成，并为治疗血管疾病提供了一种新颖而有前途的治疗方法。不同动物模型的研究表明，通过药理学药物和自体 EPC 移植动员 EPC 有助于在缺血性损伤后恢复血液供应和组织再生。然而，这些前体细胞在临床研究中的作用效果不一。EPC 的治疗效果与募集到缺血区域的前体细胞数量及其在损伤组织中的功能能力和存活能力密切相关。在这篇综述中，我们讨论了基质细胞衍生因子-1（也称为 CXCL12、SDF-1）在 EPC 动员、募集、归巢、血管修复和新生血管形成中的调节作用，并分析了这些功能的潜在机制。还讨论了应用 SDF-1 来改善血管损伤后 EPC 的再生功能。SDF-1 在动员 EPC 从骨髓进入外周循环、将前体细胞募集到靶组织以及在病理条件下防止细胞死亡方面起着至关重要的作用；从而提高 EPC 的再生能力。SDF-1 对于调节 EPC 的再生功能至关重要，并为提高前体细胞在治疗血管疾病中的治疗效果提供了一个潜在的靶点。
