Chen Ruiling, Fu Yalin, Hu Ling, Chen Yuqing, Li Pengyun
The Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China.
Clinical Medical College, Southwest Medical University, Luzhou 646000, China.
Int J Mol Sci. 2025 Jun 23;26(13):6002. doi: 10.3390/ijms26136002.
Growing evidence underscores the pivotal roles of both in situ-resident and -non-resident cardiac cells in the repair mechanisms following myocardial infarction (MI). MI continues to be a predominant cause of death and disability, posing a significant threat to global health and well-being. Despite advances in medical care, current therapies remain insufficient in preventing ventricular remodeling and heart failure post-MI. We seek to clarify the underlying regenerative mechanisms by which distinct cell types contribute to the repair of MI injury and to systematically assess the translational potential and therapeutic efficacy of these cell-based approaches in clinical applications. This review conducts a comprehensive analysis of recent research progress on the roles of non-cardiac stem cells in situ and cardiac cells derived from explants in MI repair. These cells contribute to the repair process through multiple mechanisms, including cell proliferation and differentiation, angiogenesis, paracrine signaling, immune regulation and fibrosis modulation. Our analysis reveals the intricate mechanisms of MI repair and highlights the necessity for developing age-specific therapeutic strategies for certain cell types. This review offers novel insights into cell-based treatment for MI and provides a scientific foundation for future clinical trials of cardiac regenerative medicine.
越来越多的证据强调了原位驻留和非驻留心脏细胞在心肌梗死（MI）后修复机制中的关键作用。MI仍然是死亡和残疾的主要原因，对全球健康和福祉构成重大威胁。尽管医疗护理取得了进展，但目前的治疗方法在预防MI后心室重构和心力衰竭方面仍然不足。我们试图阐明不同细胞类型促进MI损伤修复的潜在再生机制，并系统评估这些基于细胞的方法在临床应用中的转化潜力和治疗效果。本综述对非心脏干细胞原位和外植体来源的心脏细胞在MI修复中的作用的最新研究进展进行了全面分析。这些细胞通过多种机制促进修复过程，包括细胞增殖和分化、血管生成、旁分泌信号传导、免疫调节和纤维化调节。我们的分析揭示了MI修复的复杂机制，并强调了针对某些细胞类型制定年龄特异性治疗策略的必要性。本综述为基于细胞的MI治疗提供了新的见解，并为未来心脏再生医学的临床试验提供了科学依据。
