Salas I, Brenes J R, Morales O M
Departamento de Farmacología, Escuela de Medicina, San José, Costa Rica.
Rev Biol Trop. 1987 Jun;35(1):127-30.
A lyophilized aqueous leaf extract of Cecropia obtusifolia proved to be antihypertensive when intravenously administrated to conscious spontaneous hypertensive rats. Forty-five minutes after injection, the maximum fall in arterial pressure (-23.5% relative to preinjection values) was seen and recovery was not complete by the end of the 180 min observation period. The extract was also given to pre-hypertensive SHR and normotensive rats. The fall in blood pressure was more conspicuous in the two SHr groups and was not accompanied by changes in cardiac frequency in any group. This would appear to rule out either a direct or indirect involvement of the heart in regard to the observed hypotension.
钝叶蚁栖树的冻干水叶提取物经静脉注射给清醒的自发性高血压大鼠后，被证明具有降压作用。注射后45分钟，动脉血压出现最大降幅（相对于注射前值降低23.5%），在180分钟观察期结束时恢复不完全。该提取物也给予了高血压前期SHR和血压正常的大鼠。在两个SHR组中血压下降更为明显，且任何组的心率均无变化。这似乎排除了心脏直接或间接参与所观察到的低血压的可能性。
