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肿瘤药剂师对临床医生在增强患者自我给药口服肿瘤药物参与度方面的知识、态度和实践的影响。

Impact of Oncology Pharmacists on the Knowledge, Attitude, and Practices of Clinicians to Enhance Patient Engagement of Self-Administered Oral Oncolytics.

作者信息

Palmer Shannon, Chen Ashley, Dennison Taylor, Czech Cameron, Auten Jessica, Buhlinger Kaitlyn, Muluneh Benyam

机构信息

Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC 27514, USA.

UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27514, USA.

出版信息

Pharmacy (Basel). 2021 Jul 23;9(3):130. doi: 10.3390/pharmacy9030130.

DOI:10.3390/pharmacy9030130
PMID:34449698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8396350/
Abstract

Oncology clinical pharmacists are uniquely positioned to make interventions to impact the knowledge, attitudes, and practices of clinicians as well as patient activation and engagement. To accomplish this goal, pharmacists can target health system-related, provider-related, and patient-related factors to enhance patient-centered care and drive behavioral health changes. Interventions that pharmacists must tackle include educating team members and patients on the medication acquisition process, communicating urgency of treatment, optimizing workflows, facilitating guideline recommendations, preventing, and managing treatment toxicities, and promoting patient self-advocacy through education and shared decision-making. As crucial members of the healthcare team, oncology pharmacists can simplify highly complex treatment regimens to facilitate and optimize patients' ownership of their care. This narrative review will focus on the example of venetoclax treatment in acute myeloid leukemia to demonstrate the impact that pharmacists provide that leads to behavioral change of patients and clinicians.

摘要

肿瘤临床药师在进行干预以影响临床医生的知识、态度和实践以及患者的积极性和参与度方面具有独特的地位。为实现这一目标,药师可以针对与卫生系统、医疗服务提供者和患者相关的因素,以加强以患者为中心的护理并推动行为健康改变。药师必须应对的干预措施包括就药物获取过程对团队成员和患者进行教育、传达治疗的紧迫性、优化工作流程、促进指南建议的实施、预防和管理治疗毒性,以及通过教育和共同决策促进患者自我维权。作为医疗团队的关键成员,肿瘤药师可以简化高度复杂的治疗方案,以促进和优化患者对自身护理的掌控。本叙述性综述将聚焦于维奈克拉治疗急性髓系白血病的实例,以展示药师所提供的导致患者和临床医生行为改变的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef08/8396350/97518bceae8b/pharmacy-09-00130-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef08/8396350/97518bceae8b/pharmacy-09-00130-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef08/8396350/97518bceae8b/pharmacy-09-00130-g001.jpg

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本文引用的文献

1
Pharmacist Interventions to Improve Specialty Medication Adherence: Study Protocol for a Randomized Controlled Trial.药剂师干预以提高专科药物依从性:一项随机对照试验的研究方案
Drugs Real World Outcomes. 2020 Dec;7(4):295-305. doi: 10.1007/s40801-020-00213-8.
2
Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia.阿扎胞苷和维奈托克治疗未经治急性髓系白血病。
N Engl J Med. 2020 Aug 13;383(7):617-629. doi: 10.1056/NEJMoa2012971.
3
Risk of tumor lysis syndrome in patients with acute myeloid leukemia treated with venetoclax-containing regimens without dose ramp-up.
在接受不含剂量递增的含维奈克拉方案治疗的急性髓系白血病患者中发生肿瘤溶解综合征的风险。
Ann Hematol. 2021 Feb;100(2):595-599. doi: 10.1007/s00277-020-04181-5. Epub 2020 Jul 23.
4
Oral adherence in adults with acute myeloid leukemia (AML): results of a mixed methods study.成人急性髓细胞白血病(AML)患者的口服依从性:一项混合方法研究的结果。
Support Care Cancer. 2020 Nov;28(11):5157-5164. doi: 10.1007/s00520-020-05349-5. Epub 2020 Feb 14.
5
Interventions to Enhance Adherence to Oral Antineoplastic Agents: A Scoping Review.干预措施以提高口服抗肿瘤药物的依从性:范围综述。
J Natl Cancer Inst. 2020 May 1;112(5):443-465. doi: 10.1093/jnci/djz244.
6
An Integrated Health-System Specialty Pharmacy Model for Coordinating Transitions of Care: Specialty Medication Challenges and Specialty Pharmacist Opportunities.一种用于协调医疗护理过渡的综合医疗系统专科药房模式:专科药物挑战与专科药剂师机遇
Pharmacy (Basel). 2019 Dec 3;7(4):163. doi: 10.3390/pharmacy7040163.
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How I treat acute myeloid leukemia in the era of new drugs.如何在新药时代治疗急性髓系白血病。
Blood. 2020 Jan 9;135(2):85-96. doi: 10.1182/blood.2019001239.
8
Venetoclax for the treatment of newly diagnosed acute myeloid leukemia in patients who are ineligible for intensive chemotherapy.维奈克拉用于治疗不符合强化化疗条件的新诊断急性髓系白血病患者。
Ther Adv Hematol. 2019 Oct 23;10:2040620719882822. doi: 10.1177/2040620719882822. eCollection 2019.
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How we use venetoclax with hypomethylating agents for the treatment of newly diagnosed patients with acute myeloid leukemia.我们如何将维奈托克与低甲基化剂联合用于治疗新诊断的急性髓系白血病患者。
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Venetoclax-induced tumour lysis syndrome in acute myeloid leukaemia.维奈托克诱导的急性髓系白血病肿瘤溶解综合征
Br J Haematol. 2020 Jan;188(1):173-177. doi: 10.1111/bjh.16235. Epub 2019 Oct 16.