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Flies in the ointment: AAV vector preparations and tumor risk.

作者信息

Zhang Junping, Yu Xiangping, Herzog Roland W, Samulski R Jude, Xiao Weidong

机构信息

Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA.

Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.

出版信息

Mol Ther. 2021 Sep 1;29(9):2637-2639. doi: 10.1016/j.ymthe.2021.08.016. Epub 2021 Aug 26.

Abstract
摘要

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本文引用的文献

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A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells.
Nat Biotechnol. 2021 Jan;39(1):47-55. doi: 10.1038/s41587-020-0741-7. Epub 2020 Nov 16.
2
Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B.
Mol Ther. 2020 Sep 2;28(9):2073-2082. doi: 10.1016/j.ymthe.2020.06.001. Epub 2020 Jun 10.
3
VISDB: a manually curated database of viral integration sites in the human genome.
Nucleic Acids Res. 2020 Jan 8;48(D1):D633-D641. doi: 10.1093/nar/gkz867.
4
Adeno-associated virus in the liver: natural history and consequences in tumour development.
Gut. 2020 Apr;69(4):737-747. doi: 10.1136/gutjnl-2019-318281. Epub 2019 Aug 2.
6
Recombinant Adeno-Associated Viral Integration and Genotoxicity: Insights from Animal Models.
Hum Gene Ther. 2017 Apr;28(4):314-322. doi: 10.1089/hum.2017.009.
7
Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?
Hum Gene Ther. 2015 Dec;26(12):779-81. doi: 10.1089/hum.2015.29014.kib.
8
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
Nat Genet. 2015 Oct;47(10):1187-93. doi: 10.1038/ng.3389. Epub 2015 Aug 24.
9
Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy.
J Clin Invest. 2015 Feb;125(2):870-80. doi: 10.1172/JCI79213. Epub 2015 Jan 20.

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