School of Veterinary Medicine, Department of Medical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
J Vet Emerg Crit Care (San Antonio). 2021 Nov;31(6):818-822. doi: 10.1111/vec.13137. Epub 2021 Aug 27.
To describe the clinical features of rhabdomyolysis due to albuterol toxicosis in a Greyhound.
A 4-year-old neutered male Greyhound was presented for albuterol toxicosis leading to severe hypokalemia and respiratory paralysis. After 3 hours of mechanical ventilation, pigmenturia and marked enlargement, firmness, and pain of the left thigh muscles were noted. Severe hyperkalemia and cardiac arrhythmias were identified after turning the patient. After discontinuation of mechanical ventilation, other muscles became involved, and the patient developed acute kidney injury and concern for multiple organ dysfunction syndrome over the next 5 days. On day 6, the patient was euthanized, and necropsy revealed myocardial and skeletal muscle necrosis, myoglobinuria, and acute tubular degeneration.
To the authors' knowledge, this is the first case of albuterol toxicosis leading to rhabdomyolysis.
描述一只格雷伊猎犬因沙丁胺醇中毒导致横纹肌溶解症的临床特征。
一只 4 岁已去势的雄性格雷伊猎犬因沙丁胺醇中毒导致严重低钾血症和呼吸瘫痪而就诊。经过 3 小时的机械通气后，发现患犬出现色素尿和左大腿肌肉明显肿大、坚硬和疼痛。在为患犬翻身时发现严重高钾血症和心律失常。停止机械通气后，其他肌肉也出现问题，在接下来的 5 天里，患犬发生急性肾损伤和多器官功能障碍综合征。第 6 天，患犬被安乐死，尸检显示心肌和骨骼肌坏死、肌红蛋白尿和急性肾小管变性。
据作者所知，这是首例因沙丁胺醇中毒导致横纹肌溶解症的病例。
