Département Clinique des Animaux de Compagnie, de Loisir et de Sport, Université de Lyon, VetAgro Sup, Campus Vétérinaire de Lyon, Marcy-l'Etoile, France.
Intensive Care Unit (SIAMU), Université de Lyon, VetAgro Sup, APCSe, Marcy-l'Etoile, France.
J Vet Emerg Crit Care (San Antonio). 2023 Jan;33(1):118-122. doi: 10.1111/vec.13233. Epub 2022 Jul 23.
To report a case of rhabdomyolysis and myoglobinuria following single induction dose of propofol in a dog.
A 5-year-old intact male Shih-Tzu dog was presented for pigmenturia occurring a few hours following anesthesia for comprehensive oral health assessment and treatment. After premedication with IV diazepam (0.5 mg/kg), anesthesia was induced with IV propofol (4 mg/kg) and maintained with isoflurane vaporized in oxygen. A few hours following recovery from anesthesia, the dog developed rhabdomyolysis and myoglobinuria associated with increased serum alanine aminotransferase and C-reactive protein concentrations, as well as mild hypokalemia and euglycemic glycosuria. Approximately 48 hours after IV fluid therapy, the dog was clinically normal, and myoglobinuria progressively resolved.
This is the first case description of rhabdomyolysis and myoglobinuria following a single dose of injectable propofol.
报告一例犬单次诱导剂量异丙酚后横纹肌溶解症和肌红蛋白尿。
一只 5 岁雄性西施犬，因麻醉后数小时出现色素尿而就诊，此前曾接受 IV 地西泮（0.5mg/kg）进行术前用药，随后给予 IV 异丙酚（4mg/kg）诱导麻醉，并以氧气中蒸发的异氟烷维持麻醉。麻醉苏醒后数小时，该犬出现横纹肌溶解症和肌红蛋白尿，同时伴有血清丙氨酸氨基转移酶和 C 反应蛋白浓度升高，以及轻度低钾血症和糖尿。在接受 IV 液治疗约 48 小时后，该犬临床状况正常，肌红蛋白尿逐渐消退。
这是首例关于单次注射用异丙酚后发生横纹肌溶解症和肌红蛋白尿的病例描述。
