Caltagirone C, Carlesimo A, Meloni C, Morosetti M, Taccone-Gallucci M, Vicari S, Casciani C U
Clinica Neurologica, II Università, Roma.
Riv Neurol. 1987 Sep-Oct;57(5):308-12.
Fifteen undialyzed and thirteen dialyzed patients affected by chronic renal failure were studied by means of an extensive neuropsychological battery with the aim of assessing the incidence of a deterioration of cognitive functions. Mean performances scores obtained by the two groups of patients were compared with analogous scores obtained by a group of control subjects similar as for literacy and age. The comparisons among the three groups did not reveal any difference as for performance scores obtained to various tasks nor for the global assessment derived for the entire battery. Furthermore our data do not point out any significative correlation between global performances on neuropsychological battery and blood levels of creatinine and urea nitrogen or duration of dialytic treatment of renal subjects. In conclusion, the results of our study do not show evidence of cognitive impairment in subjects affected by chronic renal failure and do not confirm the hypothesis of a detrimental effect of prolonged periods of dialytic treatment on cognitive functions.
对15名未接受透析和13名接受透析的慢性肾衰竭患者进行了广泛的神经心理测试，旨在评估认知功能恶化的发生率。将两组患者获得的平均表现分数与一组在文化程度和年龄方面相似的对照受试者获得的类似分数进行比较。三组之间的比较未发现完成各项任务所获得的表现分数以及整个测试得出的总体评估有任何差异。此外，我们的数据并未指出神经心理测试的总体表现与肌酐和尿素氮的血液水平或肾脏受试者透析治疗时长之间存在任何显著相关性。总之，我们的研究结果并未显示慢性肾衰竭患者存在认知障碍的证据，也未证实长期透析治疗对认知功能有不利影响这一假设。
