Lin Tz-Feng, Yeh Shih-Hsuan
Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan.
Master's Program of Electrical and Communications Engineering, Feng Chia University, Taichung 407, Taiwan.
Polymers (Basel). 2021 Aug 13;13(16):2705. doi: 10.3390/polym13162705.
Chemotherapy is one of the most important ways to treat cancer. At present, chemotherapy medicines are mainly administered by intravenous injection or oral administration. However, systemic medical care requires the dosage of high concentrations of drugs to defeat the malignant tumor growth. In recent years, the use of polymer composites for local and sustained drug release has become an important field of research to minimize side effects due to high-concentration chemotherapy drugs. Here, F-{H} heteronuclear Overhauser enhancement spectroscopy (HOESY) was used to study the micellular environment of the F-containing chemotherapeutic drug 5-FU in Pluronic F127, Pluronic L121, and F127/L121 binary blending composites. The distribution of 5-FU in micelles is related to the PEO and PPO segment length of Pluronic polymers and the environmental temperature. The drug release tests further confirm that if 5-FU medicines were loaded in the PPO segment inside the micelles, the purpose of the prolonged drug release carrier is achieved.
化疗是治疗癌症最重要的方法之一。目前，化疗药物主要通过静脉注射或口服给药。然而，全身医疗需要高浓度药物剂量来战胜恶性肿瘤的生长。近年来，使用聚合物复合材料进行局部和持续药物释放已成为一个重要的研究领域，以尽量减少高浓度化疗药物带来的副作用。在此，利用F-{H}异核Overhauser增强光谱（HOESY）研究了含氟化疗药物5-氟尿嘧啶在普朗尼克F127、普朗尼克L121和F127/L121二元共混复合材料中的微细胞环境。5-氟尿嘧啶在胶束中的分布与普朗尼克聚合物的PEO和PPO链段长度以及环境温度有关。药物释放试验进一步证实，如果将5-氟尿嘧啶药物负载在胶束内部的PPO链段中，就可以实现延长药物释放载体的目的。
