Rub Malik Abdul, Azum Naved, Kumar Dileep, Nadeem Arshad Muhammad, Khan Anish, Alotaibi Maha Moteb, Asiri Abdullah M
Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Polymers (Basel). 2021 Nov 21;13(22):4025. doi: 10.3390/polym13224025.
In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol·kg aqueous NaCl/0.250 mol·kg aqueous urea (U)) were examined thoroughly at a temperature of 298 K. UV-Visible studies in an aqueous system of IMP + TX-100 mixtures were also investigated and discussed in detail. The pure (IMP and TX-100) along with the mixtures' critical micelle concentration () were assessed by a tensiometric technique. The obtained deviation of the mixtures' values from their ideal values revealed the nonideal behavior of IMP + TX-100 mixtures amongst IMP and TX-100. Compared to aqueous systems, in the presence of aqueous NaCl, several changes in micelles/mixed micelles occurred, and hence a synergism/attractive interaction amongst components was found increased while in the existence of U, the synergism/attractive interaction between them decreased. The evaluated interaction parameter () value of mixed micelles showed the attractive or synergism between the IMP and TX-100. Various evaluated thermodynamic parameters in an aqueous system showed that the mixed micellization of the IMP + TX-100 mixture was an entropically spontaneous phenomenon, although the existence of salt in all studied systems can somewhat increase the spontaneity of the micellization process and in the aqueous U system, the spontaneity of the micellization process decreased. In an aqueous system, the interaction between IMP and TX-100 was also confirmed by UV-Visible study.
本文通过张力测定法，在298 K的温度下，对盐酸丙咪嗪（IMP，抗抑郁药）与非离子表面活性剂吐温X-100（TX-100）以五种不同比例混合于不同溶剂（水/0.050 mol·kg 氯化钠水溶液/0.250 mol·kg 尿素（U）水溶液）中的相互作用进行了深入研究。还对IMP + TX-100混合物水体系进行了紫外可见光谱研究并详细讨论。通过张力测定技术评估了纯物质（IMP和TX-100）以及混合物的临界胶束浓度（）。混合物的 值与其理想值的偏差表明IMP + TX-100混合物在IMP和TX-100之间呈现非理想行为。与水体系相比，在氯化钠水溶液存在下，胶束/混合胶束发生了一些变化，因此发现组分之间的协同作用/吸引相互作用增强，而在尿素存在下，它们之间的协同作用/吸引相互作用减弱。混合胶束的评估相互作用参数（）值表明IMP和TX-100之间存在吸引或协同作用。水体系中各种评估的热力学参数表明，IMP + TX-100混合物的混合胶束化是一种熵驱动的自发现象，尽管在所有研究体系中盐的存在会在一定程度上增加胶束化过程的自发性，而在尿素水溶液体系中，胶束化过程的自发性降低。在水体系中，紫外可见光谱研究也证实了IMP和TX-100之间的相互作用。
