Voicu Mihai Anda Ionelia, Gȃrea Sorina Alexandra, Vasile Eugeniu, Ghebaur Adi, Iovu Horia
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
Advanced Polymer Materials Group, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
Polymers (Basel). 2021 Aug 20;13(16):2803. doi: 10.3390/polym13162803.
In this study, some hybrid materials based on sodium alginate (NaAlg) and porous clay heterostructures (PCHs) were investigated as new hosts for 5-Fluorouracil (5-FU) encapsulation. The hybrid hosts were prepared by ionotropic gelation technique using different concentrations of PCHs (1, 3, and 10 wt%) in order to identify the optimal parameters for encapsulation and drug release. The obtained hybrid materials were characterized using FTIR Spectrometry, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and UV-Vis spectrometry to investigate the interactions of the raw materials involved in the preparation of hybrid hosts, the influence of PCHs concentrations on drug encapsulation efficiency and drug release profile. All the results show that the synthesized hybrid materials were able to load a high amount of 5-FU, the encapsulation efficiency and the release profile being influenced by the concentrations of PCHs.
在本研究中，对一些基于海藻酸钠（NaAlg）和多孔粘土异质结构（PCHs）的杂化材料作为5-氟尿嘧啶（5-FU）包封的新型载体进行了研究。通过离子凝胶化技术，使用不同浓度的PCHs（1%、3%和10%重量）制备杂化载体，以确定包封和药物释放的最佳参数。使用傅里叶变换红外光谱（FTIR）、热重分析（TGA）、扫描电子显微镜（SEM）和紫外可见光谱（UV-Vis）对所得杂化材料进行表征，以研究参与制备杂化载体的原材料之间的相互作用、PCHs浓度对药物包封效率和药物释放曲线的影响。所有结果表明，合成的杂化材料能够负载大量的5-FU，包封效率和释放曲线受PCHs浓度的影响。
Zotero 插件
