Tobinski Ann-Marie, Rappeneau Virginie
Department of Behavioural Biology, University of Osnabrück, 49 076 Osnabrück, Germany.
Pharmaceuticals (Basel). 2021 Aug 8;14(8):780. doi: 10.3390/ph14080780.
The neuropeptide S (NPS) and its receptor (NPSR1) have been extensively studied over the last two decades for their roles in locomotion, arousal/wakefulness and anxiety-related and fear-related behaviours in rodents. However, the possible implications of the NPS/NPSR1 system, especially those of the single nucleotide polymorphism (SNP) rs324981, in stress-related disorders and substance abuse in humans remain unclear. This is possibly due to the fact that preclinical and clinical research studies have remained separated, and a comprehensive description of the role of the NPS/NPSR1 system in stress-relevant and reward-relevant endpoints in humans and rodents is lacking. In this review, we describe the role of the NPS/NPSR1 system in emotionality, stress responsiveness and addiction-like behaviour in rodents. We also summarize the alterations in the NPS/NPSR1 system in individuals with stress-related disorders, as well as the impact of the SNP rs324981 on emotion, stress responses and neural activation in healthy individuals. Moreover, we discuss the therapeutic potential and possible caveats of targeting the NPS/NPSR1 system for the treatment of stress-related disorders. The primary goal of this review is to highlight the importance of studying some rodent behavioural readouts modulated by the NPS/NPSR1 system and relevant to stress-related disorders.
在过去二十年中，神经肽S（NPS）及其受体（NPSR1）在啮齿动物的运动、觉醒/清醒以及与焦虑和恐惧相关的行为中的作用得到了广泛研究。然而，NPS/NPSR1系统，尤其是单核苷酸多态性（SNP）rs324981在人类应激相关障碍和药物滥用中的潜在影响仍不清楚。这可能是由于临床前研究和临床研究一直相互分离，并且缺乏对NPS/NPSR1系统在人类和啮齿动物与应激相关及与奖赏相关的终点中的作用的全面描述。在本综述中，我们描述了NPS/NPSR1系统在啮齿动物的情绪、应激反应性和成瘾样行为中的作用。我们还总结了患有应激相关障碍的个体中NPS/NPSR1系统的改变，以及SNP rs324981对健康个体的情绪、应激反应和神经激活的影响。此外，我们讨论了针对NPS/NPSR1系统治疗应激相关障碍的治疗潜力和可能存在的问题。本综述的主要目标是强调研究一些受NPS/NPSR1系统调节且与应激相关障碍相关的啮齿动物行为读数的重要性。
