Nikbakhtzadeh Marjan, Ranjbar Hoda, Moradbeygi Khadijeh, Zahedi Elham, Bayat Mahnaz, Soti Monavareh, Shabani Mohammad
Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
Neuroscience Research Center of Kerman, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran.
Heliyon. 2023 Apr 17;9(4):e15525. doi: 10.1016/j.heliyon.2023.e15525. eCollection 2023 Apr.
Addiction is a worldwide problem that has a negative impact on society by imposing significant costs on health care, public security, and the deactivation of the community economic cycle. Stress is an important risk factor in the development of addiction and relapse vulnerability. Here we review studies that have demonstrated the diverse roles of stress in addiction. Term searches were conducted manually in important reference journals as well as in the Google Scholar and PubMed databases, between 2010 and 2022. In each section of this narrative review, an effort has been made to use pertinent sources. First, we will provide an overview of changes in the Hypothalamus-Pituitary-Adrenal (HPA) axis component following stress, which impact reward-related regions including the ventral tegmental area (VTA) and nucleus accumbens (NAc). Then we will focus on internal factors altered by stress and their effects on drug addiction vulnerability. We conclude that alterations in neuro-inflammatory, neurotrophic, and neurotransmitter factors following stress pathways can impact related mechanisms on craving and relapse susceptibility.
成瘾是一个全球性问题，它通过给医疗保健、公共安全以及社区经济循环的停滞带来巨大成本，对社会产生负面影响。压力是成瘾发展和复吸易感性的一个重要风险因素。在此，我们回顾了一些研究，这些研究证明了压力在成瘾过程中的多种作用。在2010年至2022年期间，我们手动检索了重要的参考文献期刊以及谷歌学术和PubMed数据库。在这篇叙述性综述的每个部分，都努力使用了相关资料来源。首先，我们将概述应激后下丘脑-垂体-肾上腺（HPA）轴成分的变化，这些变化会影响包括腹侧被盖区（VTA）和伏隔核（NAc）在内的与奖赏相关的区域。然后，我们将关注因压力而改变的内部因素及其对药物成瘾易感性的影响。我们得出结论，应激途径后神经炎症、神经营养和神经递质因素的改变会影响与渴望和复吸易感性相关的机制。
