Poulsen Nautrup Barbara, Van Vlaenderen Ilse, Mah Choewkong, Angulo Jose
EAH-Consulting, 52064 Aachen, Germany.
CHESS, 2820 Bonheiden, Belgium.
Vaccines (Basel). 2021 Aug 19;9(8):923. doi: 10.3390/vaccines9080923.
Vaccination against porcine circovirus type 2 (PCV2) is commonly performed in piglets worldwide, and increasingly also in sows. We conducted a literature search and review to assess the potential interference of maternally derived antibodies (MDA) in piglets with vaccination against PCV2. The effectiveness of vaccination was compared to no vaccination in the presence of high levels of MDA (≥8 log IPMA titer), as reported in field studies. In total, 13 papers fulfilled the predefined inclusion criteria, allowing up to 24 comparisons per parameter. In the presence of high levels of MDA, vaccinated pigs had, on average, a 20 g/d higher mean daily weight gain and a 34% lower mortality compared to non-vaccinates. The maximum percentage of viremic pigs was reduced by 63% and the maximum viral load in serum was 0.72 log PCV2 DNA copies lower. Vaccination at 3 weeks of age was associated with the highest improvements in production parameters and reductions in viremia. Our findings suggest that the vaccination of piglets is effective with respect to production parameters and viremia even in the presence of high MDA, with an age of 3 weeks at vaccination being most beneficial.
全球范围内，仔猪普遍接种猪圆环病毒2型（PCV2）疫苗，母猪接种该疫苗的情况也日益增多。我们进行了文献检索和综述，以评估仔猪母源抗体（MDA）对PCV2疫苗接种的潜在干扰。如实地研究报告所述，在高水平MDA（≥8 log IPMA滴度）存在的情况下，将疫苗接种的效果与未接种疫苗的情况进行了比较。总共有13篇论文符合预定义的纳入标准，每个参数最多可进行24次比较。在高水平MDA存在的情况下，与未接种疫苗的猪相比，接种疫苗的猪平均日增重高20克/天，死亡率低34%。病毒血症猪的最大百分比降低了63%，血清中的最大病毒载量降低了0.72 log PCV2 DNA拷贝。3周龄时接种疫苗与生产参数的最大改善和病毒血症的降低相关。我们的研究结果表明，即使存在高水平的MDA，仔猪接种疫苗在生产参数和病毒血症方面也是有效的，3周龄时接种疫苗最为有益。
