出血性天花沙鼠模型中的急性晚期心肌炎。
Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox.
机构信息
Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.
Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
出版信息
Viruses. 2021 Aug 9;13(8):1571. doi: 10.3390/v13081571.
Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox.
出血性天花由天花病毒（VARV）引起，是一种罕见但几乎 100%致命的人类疾病表现。出血性天花常伴有继发性细菌感染、凝血功能障碍以及心肌和心内膜下出血。先前的实验表明，猕猴静脉内（IV）接种牛痘病毒（CPXV）可模拟人类出血性天花。本实验的目的是进一步了解心脏病理的发生、性质和严重程度，以及其如何导致疾病。研究结果支持在 CPXV 出血性天花模型中存在急性晚期心肌炎伴淋巴组织细胞浸润。
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