Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, NY, USA
Department of Pediatrics, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, New York, NY, USA.
Ann Clin Lab Sci. 2021 Jul;51(4):540-545.
(), an extracellular pathogen lacking a cell wall, causes respiratory infection in adults and children and has been implicated in asthma exacerbation; immunoglobulin (Ig) E may be involved in these exacerbations. Specific IgM and IgG immune response to has been reported, but less is known about IgE antibody (Ab) responses in asthma. Previous studies in our laboratory demonstrated that asthmatic children have increased IgM levels, but not IgE. Thus, we sought to investigate whether past infection triggers production of -specific IgE Abs in adult subjects with/without asthma.
-IgE Ab levels were low and below the threshold of detection in both asthmatic and non-asthmatics (0.0020.008 vs. 0.020.03; =0.021). However, specific-IgM levels were slightly higher in non-asthmatics compared with asthmatics (0.960.37 vs. 0.790.31; =0.054). -IgM Ab positivity was similar in both groups (=1.0).
IgM Abs may play an important role in non-asthma and persist for months after acute infection. IgE Abs may play a less important role in both groups.
无细胞壁的胞外病原体，引起成人和儿童呼吸道感染，并与哮喘加重有关；免疫球蛋白（Ig）E 可能参与这些加重。已经报道了针对 的特异性 IgM 和 IgG 免疫反应，但哮喘中 IgE 抗体（Ab）反应的了解较少。我们实验室的先前研究表明，哮喘儿童 IgM 水平增加，但 IgE 没有。因此，我们试图研究过去的 感染是否会在有/无哮喘的成年患者中引发针对 的 IgE Ab 产生。
使用 ELISA 研究了成年哮喘（N=22）和非哮喘（N=22）患者的 -IgE 和 -IgM Ab 反应。数据以抗体指数报告。检测阈值：IgE、IgM：分别为 0.2、0.9。
哮喘和非哮喘患者的 -IgE Ab 水平均较低且低于检测阈值（0.002-0.008 对 0.02-0.03；=0.021）。然而，非哮喘患者的特异性-IgM 水平略高于哮喘患者（0.960.37 对 0.790.31；=0.054）。两组的 -IgM Ab 阳性率相似（=1.0）。
IgM Ab 可能在非哮喘中发挥重要作用，并在急性感染后持续数月。IgE Ab 在两组中的作用可能较小。
