Gafni Tal, Shuval Kerem, Weinstein Galit, Barlow Carolyn E, Gabriel Kelley Pettee, Willis Benjamin L, Leonard David, Haskell William L, DeFina Laura F
J Aging Phys Act. 2022 Jun 1;30(3):355-363. doi: 10.1123/japa.2020-0473. Epub 2021 Aug 27.
This study cross-sectionally examines the relations of sitting and physical activity (PA) with cognitive impairment in community-dwelling adults aged 55-87 years (n = 3,780). Multivariable logistic regression assessed independent and joint relations of sitting and PA with Montreal Cognitive Assessment scores adjusting for covariates. Sitting ≥75% of the time and not meeting PA guidelines were related to 60% (95% confidence interval [CI] [1.19, 2.17]) and 27% (95% CI [1.06, 1.53]) higher odds for cognitive impairment, respectively. Stratification by age showed that sitting ≥75% of the time was associated with higher cognitive impairment odds in midlife (odds ratio [OR] = 1.86; 95% CI [1.31, 2.65]), but not older adults (OR = 1.06; 95% CI [0.57, 1.95]). Joint association analysis revealed that, overall, the highest odds for cognitive impairment were in those sitting ≥75% of the time while meeting or not meeting PA guidelines (OR = 1.69, 95% CI [1.13, 2.53]; and OR = 1.66, 95% CI [1.19, 2.32], respectively). In conclusion, prolonged sitting and insufficient PA are independent risk markers for cognitive impairment.
本研究采用横断面研究方法，调查了55至87岁社区居住成年人（n = 3780）的久坐行为和身体活动（PA）与认知障碍之间的关系。多变量逻辑回归分析评估了久坐行为和PA与蒙特利尔认知评估得分之间的独立关系和联合关系，并对协变量进行了校正。久坐时间≥75%且未达到PA指南标准分别与认知障碍几率高60%（95%置信区间[CI][1.19, 2.17]）和27%（95% CI[1.06, 1.53]）相关。按年龄分层显示，久坐时间≥75%与中年人群认知障碍几率较高相关（优势比[OR]=1.86；95% CI[1.31, 2.65]），但与老年人无关（OR = 1.06；95% CI[0.57, 1.95]）。联合关联分析显示，总体而言，认知障碍几率最高的是那些久坐时间≥75%且达到或未达到PA指南标准的人群（分别为OR = 1.69，95% CI[1.13, 2.53]；以及OR = 1.66，95% CI[1.19, 2.32]）。总之，久坐时间过长和PA不足是认知障碍的独立风险标志。
