亚马孙地区东部和圣保罗地区δ抗体意外低流行率：巴西境内δ型肝炎病毒流行病学存在区域差异的证据。

Unexpected low prevalence of delta antibodies in the east Amazon region and São Paulo: evidence for regional differences in the epidemiology of delta hepatitis virus within Brazil.

作者信息

Strauss E, Gayotto L C, da Silva L C, Alves V A, Carrilho F, Chamone D A, da Silva E F, Porta G, Granato C, Trepo C

机构信息

Liver Unit, School of Medicine, University of São Paulo, Brazil.

出版信息

Trans R Soc Trop Med Hyg. 1987;81(1):73-4. doi: 10.1016/0035-9203(87)90288-4.

DOI:10.1016/0035-9203(87)90288-4

PMID:3445327

Abstract

Antibodies (anti-HD) to hepatitis delta virus (HDV) were tested by radioimmunoassay in 207 human serum samples from the eastern Amazon (states of Pará and Amapá) and São Paulo, Brazil. 42 Amazon HBsAg asymptomatic carriers were negative for anti-HD. 84 São Paulo HBsAg asymptomatic carriers were also negative. Among the 81 HBsAg patients from São Paulo with different liver diseases, only one had anti-HD. Liver biopsy of this chronic active hepatitis case was positive for HBsAg, HBcAg and HDAg in liver, by an immunoperoxidase technique. The low prevalence of HDV infections in São Paulo and eastern Amazon was unexpected and contrasts with the recent reports of high prevalence in the western Amazon region. Such regional differences emphasize the need for extensive and precise worldwide epidemiological studies of HDV.

摘要

采用放射免疫分析法对来自巴西亚马孙东部（帕拉州和阿马帕州）以及圣保罗的207份人类血清样本检测了针对丁型肝炎病毒（HDV）的抗体（抗-HD）。42名亚马孙地区无症状HBsAg携带者抗-HD检测呈阴性。84名圣保罗无症状HBsAg携带者检测也呈阴性。在圣保罗81名患有不同肝脏疾病的HBsAg患者中，仅1人抗-HD呈阳性。通过免疫过氧化物酶技术对该慢性活动性肝炎病例进行肝活检，结果显示肝脏中HBsAg、HBcAg和HDAg呈阳性。圣保罗和亚马孙东部地区HDV感染的低流行率出人意料，这与最近关于亚马孙西部地区高流行率的报道形成对比。这种地区差异凸显了对HDV进行广泛而精确的全球流行病学研究的必要性。