Department of Veterinary Sciences, University of Turin, Grugliasco, Italy.
Adv Exp Med Biol. 2021;1331:215-229. doi: 10.1007/978-3-030-74046-7_14.
BDNF and GDNF display the notable qualities of undergoing a regulated secretion in neurons and being anterogradely transported to nerve terminals, where they can modulate fast synaptic transmission. That BDNF positively modulates nociception and/or pain is today widely accepted, as the growth factor can start and maintain physiological and pathological pain. The contribution of GDNF to nociception is by far most elusive, but evidence is accumulating that the molecule displays analgesic activity, at least in rodents. Here I resume the current knowledge on the spinal cord circuits in which these two factors may act as modulators of pain-related synaptic transmission, focusing on their structural and functional interplay in the regulation of nociception and pain.
BDNF 和 GDNF 具有受调控的分泌和向神经末梢顺行运输的显著特性，在神经末梢它们可以调节快速突触传递。BDNF 可以正向调节伤害感受和/或疼痛，这在今天已被广泛接受，因为这种生长因子可以启动和维持生理和病理性疼痛。到目前为止，GDNF 对伤害感受的贡献还很难捉摸，但有证据表明，这种分子至少在啮齿类动物中具有镇痛活性。在这里，我总结了这两种因子可能作为伤害感受相关突触传递调节剂的脊髓回路的最新知识，重点介绍了它们在调节伤害感受和疼痛中的结构和功能相互作用。
