Department of Gynecology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 261 Huansha Rd, Hangzhou, 310006, Zhejiang, China.
Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Arch Gynecol Obstet. 2022 Mar;305(3):683-691. doi: 10.1007/s00404-021-06215-3. Epub 2021 Aug 28.
The effect of serum lipids on ovarian cancer is controversial. We conducted this study to evaluate the prognostic value of preoperative plasma lipid profile in patients with ovarian cancer.
The medical records of 156 epithelial ovarian cancer patients who underwent surgical resection in our department were retrospectively reviewed and analyzed. Serum lipids profiles, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-I (apoA-I), apolipoprotein B (apoB) and clinicopathologic data, were analyzed. Cox proportional hazards regression analyses and Kaplan-Meier method were performed to evaluate the overall survival (OS) and progression-free survival (PFS).
Multivariable Cox regression analysis found that preoperative higher LDL-C level was significantly associated with worse OS (HR 2.088, 95% CI 1.052-4.147, p = 0.035), whereas higher HDL-C level showed significant association with better PFS (HR 0.491, 95% CI 0.247-0.975, p = 0.042). Further Kaplan-Meier survival analysis demonstrated that OS was longer for patients with low levels of LDL-C (< 2.76 mmol/L) compared to those with high levels of LDL-C (≥ 2.76 mmol/L) (P = 0.028), and PFS was better for patients with high levels of HDL-C (≥ 1.19 mmol/L) compared to those with low levels of HDL-C (< 1.19 mmol/L) (P = 0.001).
Preoperative HDL-C and LDL-C levels are significant predictors of clinical outcome in patients with epithelial ovarian cancer.
血清脂质对卵巢癌的影响存在争议。我们进行这项研究旨在评估术前血浆脂质谱在卵巢癌患者中的预后价值。
回顾性分析了我院 156 例上皮性卵巢癌患者的病历资料，分析了总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、载脂蛋白 A-I（apoA-I）、载脂蛋白 B（apoB）等血清脂质谱及临床病理资料。采用 Cox 比例风险回归分析和 Kaplan-Meier 法评估总生存期（OS）和无进展生存期（PFS）。
多变量 Cox 回归分析发现，术前较高的 LDL-C 水平与较差的 OS 显著相关（HR 2.088，95%CI 1.052-4.147，p=0.035），而较高的 HDL-C 水平与较好的 PFS 显著相关（HR 0.491，95%CI 0.247-0.975，p=0.042）。进一步的 Kaplan-Meier 生存分析表明，LDL-C 水平较低（<2.76 mmol/L）的患者 OS 较长，而 LDL-C 水平较高（≥2.76 mmol/L）的患者 OS 较短（P=0.028）；HDL-C 水平较高（≥1.19 mmol/L）的患者 PFS 较好，而 HDL-C 水平较低（<1.19 mmol/L）的患者 PFS 较差（P=0.001）。
术前 HDL-C 和 LDL-C 水平是上皮性卵巢癌患者临床结局的重要预测指标。
