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应用于无法进行角膜移植的疼痛性大泡性角膜病变的盲眼的鲍曼氏膜电凝术:一项回顾性病例系列研究。

Use of Bowman's membrane electrocautery in blind eyes with painful bullous keratopathy not amenable to corneal transplantation: a retrospective case series.

机构信息

Roski Eye Institute, University of Southern California, 1450 San Pablo St., Los Angeles, CA, 90033, USA.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2022 Jan;260(1):191-196. doi: 10.1007/s00417-021-05360-4. Epub 2021 Aug 28.

Abstract

PURPOSE

This study evaluated the safety and efficacy of Bowman's membrane electrocautery in blind painful eyes with bullous keratopathy not amenable to corneal transplantation.

METHODS

Eleven eyes of 11 subjects with painful bullous keratopathy and poor visual potential who underwent electrocautery of Bowman's membrane at a tertiary referral ophthalmology clinic were reviewed retrospectively. Subject demographics and preoperative and postoperative data were collected, including description of pain, slit lamp biomicroscopy, best corrected visual acuity, topical medication use, and complications. Efficacy of the procedure on pain reduction, bullae resolution, and topical medication use were assessed at post-operative visits. Safety was also evaluated based on any complications.

RESULTS

Bowman's membrane electrocautery effectively resolved bullae in all eyes examined up to 6 months postoperatively; however, 2 eyes had recurrence by 1 year. Mean age at the time of surgery was 69.8 years and mean duration of follow-up was 15.4 months. Pain reduction was achieved in all eyes at 1 month, but 1 subject had pain recurrence by 6 months and another by 1 year. The median number of drops per day decreased from 6 preoperatively to 1.7 at 6 months. Two subjects who had underlying advanced ophthalmic disease had a mild reduction in vision.

CONCLUSION

Bowman's membrane electrocautery is a safe and minimally invasive procedure for the management of painful bullous keratopathy in eyes with low vision potential and not amenable to corneal transplantation. Duration of effect appears to last at least 6 months and up to 3 years post-procedure.

摘要

目的

本研究评估了针对不适合角膜移植的伴有大疱性角膜病变的疼痛性盲眼行巩膜膜电烙术的安全性和疗效。

方法

回顾性分析了在一家三级转诊眼科诊所接受巩膜膜电烙术的 11 例 11 眼伴有疼痛性大疱性角膜病变且视力预后较差的患者。收集了患者的人口统计学资料和术前及术后数据,包括疼痛描述、裂隙灯生物显微镜检查、最佳矫正视力、局部用药情况和并发症。术后评估疼痛缓解、大疱消退和局部用药效果。根据任何并发症评估该操作的安全性。

结果

在所有接受检查的眼中,巩膜膜电烙术在术后 6 个月内有效地消退了大疱;然而,有 2 只眼在 1 年内复发。手术时的平均年龄为 69.8 岁,平均随访时间为 15.4 个月。所有眼睛在 1 个月时均实现了疼痛缓解,但 1 例在 6 个月时出现疼痛复发,另 1 例在 1 年内出现疼痛复发。每日滴眼次数中位数从术前的 6 滴减少到术后 6 个月时的 1.7 滴。2 例患有基础进展性眼病的患者视力轻度下降。

结论

巩膜膜电烙术是一种安全、微创的方法,可用于治疗视力预后差且不适合角膜移植的疼痛性大疱性角膜病变的眼睛。效果持续时间至少为 6 个月,最长可达术后 3 年。

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