Yang Guang-Fei, Zhang Xin, Su Yi-Ge, Zhao Ren, Wang Yan-Yang
Dept. of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
School of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Cancer Cell Int. 2021 Aug 28;21(1):455. doi: 10.1186/s12935-021-02160-y.
The balance between ubiquitination and deubiquitination is critical for the degradation, transport, localization, and activity of proteins. Deubiquitinating enzymes (DUBs) greatly contribute to the balance of ubiquitination and deubiquitination, and they have been widely studied due to their fundamental role in cancer. DUB3/ubiquitin-specific protease 17 (USP17) is a type of DUB that has attracted much attention in cancer research. In this review, we summarize the biological functions and regulatory mechanisms of USP17 in central nervous system, head and neck, thoracic, breast, gastrointestinal, genitourinary, and gynecologic cancers as well as bone and soft tissue sarcomas, and we provide new insights into how USP17 can be used in the management of cancer.
泛素化与去泛素化之间的平衡对于蛋白质的降解、运输、定位及活性至关重要。去泛素化酶（DUBs）对泛素化与去泛素化的平衡起着重要作用，由于其在癌症中的基础作用，已得到广泛研究。DUB3/泛素特异性蛋白酶17（USP17）是一种在癌症研究中备受关注的DUB。在本综述中，我们总结了USP17在中枢神经系统、头颈、胸部、乳腺、胃肠道、泌尿生殖系统及妇科癌症以及骨肉瘤和软组织肉瘤中的生物学功能及调控机制，并对USP17如何用于癌症治疗提供了新见解。
