Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Switzerland; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland; Brain and Mind Research, Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Division of Development and Growth, Department of Woman, Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.
Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Switzerland; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
Neuroimage. 2021 Nov;243:118471. doi: 10.1016/j.neuroimage.2021.118471. Epub 2021 Aug 27.
In the human brain, the corpus callosum is the major white-matter commissural tract enabling the transmission of sensory-motor, and higher level cognitive information between homotopic regions of the two cerebral hemispheres. Despite developmental absence (i.e., agenesis) of the corpus callosum (AgCC), functional connectivity is preserved, including interhemispheric connectivity. Subcortical structures have been hypothesised to provide alternative pathways to enable this preservation. To test this hypothesis, we used functional Magnetic Resonance Imaging (fMRI) recordings in children with AgCC and typically developing children, and a time-resolved approach to retrieve temporal characteristics of whole-brain functional networks. We observed an increased engagement of the cerebellum and amygdala/hippocampus networks in children with AgCC compared to typically developing children. There was little evidence that laterality of activation networks was affected in AgCC. Our findings support the hypothesis that subcortical structures play an essential role in the functional reconfiguration of the brain in the absence of a corpus callosum.
在人类大脑中，胼胝体是主要的白质连合束，能够在两个大脑半球的同型区域之间传递感觉运动和更高层次的认知信息。尽管胼胝体发育不全（即发育不全），但功能连接仍然存在，包括半球间连接。有人假设皮质下结构提供了替代途径来实现这种保存。为了验证这一假设，我们使用功能磁共振成像（fMRI）记录了胼胝体发育不全（AgCC）患儿和正常发育儿童的大脑，并采用时间分辨方法获取全脑功能网络的时间特征。与正常发育儿童相比，我们观察到 AgCC 患儿的小脑和杏仁核/海马网络的参与度增加。几乎没有证据表明激活网络的偏侧性在 AgCC 中受到影响。我们的发现支持这样一种假设，即皮质下结构在胼胝体缺失的情况下对大脑的功能重新配置起着至关重要的作用。
