Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.
Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Écublens, Switzerland.
Pediatr Res. 2023 Jun;93(7):2072-2080. doi: 10.1038/s41390-022-02342-y. Epub 2022 Nov 3.
Children born very preterm (VPT; <32 weeks' gestation) are at high risk of neurodevelopmental and behavioural difficulties associated with atypical brain maturation, including socio-emotional difficulties. The analysis of large-scale brain network dynamics during rest allows us to investigate brain functional connectivity and its association with behavioural outcomes.
Dynamic functional connectivity was extracted by using the innovation-driven co-activation patterns framework in VPT and full-term children aged 6-9 to explore changes in spatial organisation, laterality and temporal dynamics of spontaneous large-scale brain activity (VPT, n = 28; full-term, n = 12). Multivariate analysis was used to explore potential biomarkers for socio-emotional difficulties in VPT children.
The spatial organisation of the 13 retrieved functional networks was comparable across groups. Dynamic features and lateralisation of network brain activity were also comparable for all brain networks. Multivariate analysis unveiled group differences in associations between dynamical functional connectivity parameters with socio-emotional abilities.
In this exploratory study, the group differences observed might reflect reduced degrees of maturation of functional architecture in the VPT group in regard to socio-emotional abilities. Dynamic features of functional connectivity could represent relevant neuroimaging markers and inform on potential mechanisms through which preterm birth leads to neurodevelopmental and behavioural disorders.
Spatial organisation of the retrieved resting-state networks was comparable between school-aged very preterm and full-term children. Dynamic features and lateralisation of network brain activity were also comparable across groups. Multivariate pattern analysis revealed different patterns of association between dynamical functional connectivity parameters and socio-emotional abilities in the very preterm and full-term groups. Findings suggest a reduced degree of maturation of the functional architecture in the very preterm group in association with socio-emotional abilities.
极早产儿（VPT；<32 周妊娠）出生后存在发生与非典型脑成熟相关的神经发育和行为困难的高风险，包括社会情感困难。对休息时大规模大脑网络动力学的分析使我们能够研究大脑功能连接及其与行为结果的关联。
使用创新驱动的共同激活模式框架从 VPT 和 6-9 岁足月儿童中提取动态功能连接，以探索自发的大规模大脑活动的空间组织、偏侧性和时间动态变化（VPT，n=28；足月，n=12）。使用多元分析来探索 VPT 儿童社会情感困难的潜在生物标志物。
13 个检索到的功能网络的空间组织在组间具有可比性。所有大脑网络的网络脑活动的动态特征和偏侧性也具有可比性。多元分析揭示了动态功能连接参数与社会情感能力之间的关联在组间存在差异。
在这项探索性研究中，观察到的组间差异可能反映了 VPT 组在社会情感能力方面的功能结构成熟程度降低。功能连接的动态特征可以代表相关的神经影像学标志物，并提供有关早产导致神经发育和行为障碍的潜在机制的信息。
在这项探索性研究中，在社会情感能力方面，学龄期极早产儿和足月儿童的静息状态网络的空间组织具有可比性。网络脑活动的动态特征和偏侧性在组间也具有可比性。多元模式分析揭示了 VPT 和足月组之间动态功能连接参数与社会情感能力之间关联的不同模式。研究结果表明，与社会情感能力相关的功能结构成熟程度在 VPT 组中较低。
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