Fedurov V V
Vopr Med Khim. 1987 Nov-Dec;33(6):82-4.
Rate of degradation and half-life of ubiquinone were studied in tissues of rats, maintained on standard and artificial diet, which included either cholesterol or bile acids. Metabolism of ubiquinone was distinctly accelerated in liver, kidney tissues and skeletal muscles and was decreased in small intestine of the animals kept on the artificial cholesterol-free diet. After addition of 2% cholesterol to the ration metabolism of ubiquinone was decreased in skeletal muscles and, especially, in liver tissue. When 0.2% bile acids were included into the ration. metabolism of ubiquinone was decreased more than 13-fold in liver tissue, whereas in small intestine it was accelerated and approached the values corresponding to those of control animals.
在以标准饮食和人工饮食饲养的大鼠组织中研究了泛醌的降解速率和半衰期，这些饮食中包含胆固醇或胆汁酸。在食用不含胆固醇的人工饮食的动物的肝脏、肾脏组织和骨骼肌中，泛醌的代谢明显加快，而在小肠中则减慢。在日粮中添加2%胆固醇后，骨骼肌尤其是肝脏组织中泛醌的代谢减慢。当日粮中包含0.2%胆汁酸时，肝脏组织中泛醌的代谢减慢超过13倍，而在小肠中则加快并接近对照动物的值。
