Zou Runmei, Wang Shuo, Cai Hong, Li Fang, Lin Ping, Wang Yuwen, Wang Cheng
Department of Pediatric Cardiovasology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Front Neurosci. 2021 Aug 12;15:712462. doi: 10.3389/fnins.2021.712462. eCollection 2021.
Vitamin D deficiency is associated with the risk of cardiovascular diseases. We aimed to investigate the serum vitamin D levels in children with vasovagal syncope (VVS) and explore the correlation of vitamin D status and circadian rhythm of blood pressure in VVS pediatric patients.
This was a retrospective study. 130 syncopal children diagnosed with VVS were included in the study. 110 age and gender matched healthy individuals were enrolled as control. According to serum 25(OH)D levels, VVS patients were divided into vitamin D sufficient group and vitamin D deficient group. Detailed information of VVS children with vitamin D deficiency and sufficiency on demographic data, baseline laboratory testing, echocardiogram, ambulatory blood pressure monitoring, and Holter ECG recording were extracted and analyzed.
VVS children had a higher prevalence of vitamin D deficiency compared with healthy individuals (33.8% vs. 20.0%, = 0.017). VVS patients with vitamin D deficiency had a higher rate of non-dipper blood pressure (79.5% vs. 59.3%, = 0.021) and a lower value of square root of mean squared differences of successive normal to normal intervals (rMSSD) (median 107.8 vs. 141.0 ms, = 0.035) compared with those with vitamin D sufficiency. Logistic regression analysis showed that non-dipper blood pressure was associated with serum 25(OH)D level [OR = 0.979, 95% CI (0.960, 0.999), = 0.036].
VVS pediatric patients had a higher prevalence of vitamin D deficiency. VVS children with vitamin D deficiency showed a higher rate of non-dipper blood pressure, suggesting that vitamin D deficiency is correlated with impaired circadian rhythm of blood pressure.
维生素D缺乏与心血管疾病风险相关。我们旨在调查血管迷走性晕厥（VVS）患儿的血清维生素D水平，并探讨VVS儿科患者维生素D状态与血压昼夜节律的相关性。
这是一项回顾性研究。130例诊断为VVS的晕厥患儿纳入研究。110例年龄和性别匹配的健康个体作为对照。根据血清25(OH)D水平，VVS患者分为维生素D充足组和维生素D缺乏组。提取并分析维生素D缺乏和充足的VVS患儿在人口统计学数据、基线实验室检查、超声心动图、动态血压监测和动态心电图记录方面的详细信息。
与健康个体相比，VVS患儿维生素D缺乏的患病率更高（33.8%对20.0%，P = 0.017）。与维生素D充足的VVS患者相比，维生素D缺乏的VVS患者非勺型血压发生率更高（79.5%对59.3%，P = 0.021），连续正常RR间期的均方根差值（rMSSD）值更低（中位数107.8对141.0 ms，P = 0.035）。Logistic回归分析显示，非勺型血压与血清25(OH)D水平相关[比值比（OR）= 0.979，95%可信区间（CI）（0.960，0.999），P = 0.036]。
VVS儿科患者维生素D缺乏的患病率更高。维生素D缺乏的VVS患儿非勺型血压发生率更高，提示维生素D缺乏与血压昼夜节律受损相关。
