Usalp Songül, Kemal Hatice, Yüksek Ümit, Yaman Belma, Günsel Aziz, Edebal Oğuzhan, Akpınar Onur, Cerit Levent, Duygu Hamza
Department of Cardiology Near East University Faculty of Medicine Nicosia Cyprus.
Department of Clinical Biochemistry Near East University Faculty of Medicine Nicosia Cyprus.
J Arrhythm. 2020 Feb 10;36(2):371-376. doi: 10.1002/joa3.12309. eCollection 2020 Apr.
This study aimed to investigate serum 25[OH]D levels between patients with vasovagal syncope (VVS) diagnosed with head-up tilt table test (HUTT) and age-matched healthy people.
The study included 75 consecutive patients (32.3 ± 10.7 years), who presented with syncope and underwent HUTT and 52 healthy controls (32.9 ± 14.1 years). HUTT patients were divided into two groups according to whether there was syncope response to the test. Patients underwent cardiac, psychiatric, and neurological investigation. Serum 25[OH]D levels were measured by chemiluminescent microparticle immunoassay method.
There was no difference between the two groups in terms of age, gender, body mass index (BMI), echocardiographic findings ( > .05). Mean serum 25[OH]D (24.5 ± 6.3 vs 20.1 ± 8.8 ng/mL, = .003) and vitamin B12 levels (436.4 ± 199.2 vs 363.1 ± 107.6 pg/mL, = .009) was lower in syncope patients when compared to the control group. In correlation analyses, syncope was shown as correlated with the vitamin D ( = -264, = .003) and vitamin B12 levels ( = -233, = .009). But, multivariate regression analyses showed that only vitamin D increased risk of syncope [OR: 0.946, 95% CI (0.901-0.994)]. There was no difference in terms of age, gender, BMI, echocardiographic findings between the in HUTT positive (n = 45) and negative groups (n = 29). Only vitamin D level was significantly lower in HUTT positive group (17.5 ± 7.7 vs 24.4 ± 9.1 ng/mL, = .002). There was no difference among in the vasovagal subgroups in terms of vitamin D level and other features.
Vitamin D and B12 levels were reasonably low in syncope patients, but especially low Vitamin D levels were associated with VVS diagnosed in HUTT.
本研究旨在调查经直立倾斜试验（HUTT）诊断的血管迷走性晕厥（VVS）患者与年龄匹配的健康人之间的血清25[OH]D水平。
本研究纳入了75例连续的患者（32.3±10.7岁），这些患者出现晕厥并接受了HUTT检查，以及52例健康对照者（32.9±14.1岁）。根据对试验是否有晕厥反应，将HUTT患者分为两组。患者接受了心脏、精神和神经方面的检查。血清25[OH]D水平采用化学发光微粒子免疫分析法测定。
两组在年龄、性别、体重指数（BMI）、超声心动图检查结果方面无差异（P>0.05）。与对照组相比，晕厥患者的平均血清25[OH]D水平（24.5±6.3 vs 20.1±8.8 ng/mL，P=0.003）和维生素B12水平（436.4±199.2 vs 363.1±107.6 pg/mL，P=0.009）较低。在相关性分析中，晕厥与维生素D（r=-0.264，P=0.003）和维生素B12水平（r=-0.233，P=0.009）相关。但是，多因素回归分析显示只有维生素D增加了晕厥风险[比值比：0.946，95%可信区间（0.901-0.994）]。HUTT阳性组（n=45）和阴性组（n=29）在年龄、性别、BMI、超声心动图检查结果方面无差异。只有HUTT阳性组的维生素D水平显著较低（17.5±7.7 vs 24.4±9.1 ng/mL，P=0.002）。血管迷走亚组在维生素D水平和其他特征方面无差异。
晕厥患者的维生素D和B12水平相当低，但特别是低维生素D水平与经HUTT诊断的VVS相关。
