Done Joy Zhou, Fang Sandy H
Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, United States.
Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, United States.
World J Gastrointest Oncol. 2021 Aug 15;13(8):856-866. doi: 10.4251/wjgo.v13.i8.856.
Despite the general decrease in overall incidence of colorectal cancer since the early 1990s, the incidence of colorectal cancer in patients less than 50 years old has nearly doubled. A systematic review was performed using the PubMed database (2011-2020) and Cochrane Database of Systematic Reviews (2011-2021) to identify studies (published in English) evaluating epidemiologic, clinical, hereditary, and molecular features; as well as evaluation, management, and prognosis of young-onset colorectal cancer patients. Our search yielded a total of 3401 articles, after applying our inclusion criteria. We fully reviewed 94 full-length studies. This systematic review demonstrates the increasing incidence of young-onset colorectal cancer and highlights the importance of being hypervigilant for the differential diagnosis colorectal cancer when evaluating a young adult who presents with gastrointestinal symptoms.
尽管自20世纪90年代初以来，结直肠癌的总体发病率普遍下降，但50岁以下患者的结直肠癌发病率几乎翻了一番。利用PubMed数据库（2011 - 2020年）和Cochrane系统评价数据库（2011 - 2021年）进行了一项系统评价，以识别（以英文发表的）评估流行病学、临床、遗传和分子特征的研究；以及青年发病结直肠癌患者的评估、管理和预后。应用纳入标准后，我们的检索共得到3401篇文章。我们全面审查了94篇全文研究。这项系统评价证明了青年发病结直肠癌发病率的上升，并强调在评估出现胃肠道症状的年轻成年人时，对结直肠癌进行鉴别诊断保持高度警惕的重要性。
