Department of Surgery, El Demerdash Hospital, Ain Shams University, Abbasiya, 11566 Cairo, Egypt.
Department of Surgery, El Demerdash Hospital, Ain Shams University, Abbasiya, 11566 Cairo, Egypt.
Int J Surg. 2017 Aug;44:71-75. doi: 10.1016/j.ijsu.2017.06.028. Epub 2017 Jun 15.
Colorectal cancer in Egypt has a higher incidence in young patients compared to western countries, where the disease is more prevalent in the old age group. This difference has been attributed to higher incidence of hereditary cancers in young Egyptian patients. The aim of this study is to compare the family history criteria and pathology features of tumors in young (≤40 years) and old (>40 years) Egyptian patients with adenocarcinoma of the colon and rectum.
This is the analysis of our prospectively collected data on the pathology features of tumors in 313 consecutive patients (133 young, 180 old) with colorectal cancer presenting to the Department of Surgery within an eight-year period. A detailed family history was obtained from 258 patients (112 young, 146 old).
41 young and 48 old patients reported family history of cancer, the difference was not statistically significant. Ten young patients (9%) reported a family history of colorectal cancer in a first degree relative (3 fitting into Amsterdam criteria, 7 fitting into less strict criteria) which was not significantly different from the old age group. The pathologic features of tumors in both groups resembled sporadic rather than hereditary cancer and there was no significant difference between groups in tumor location, degree of differentiation, mucin production, synchronous and metachronous colorectal tumors or polyps and grossly stricturing or ulcerating tumors. Extracolonic tumors developed in one young and two old patients.
The characteristics of large bowel cancer in young Egyptian patients do not differ significantly from those in older patients. Despite the high incidence of large bowel cancer in young Egyptian patients, family history and pathologic features of tumors do not support a hereditary origin of colorectal cancer in this age group in Egypt.
与西方国家相比，埃及的结直肠癌在年轻患者中发病率更高，在西方国家，这种疾病更常见于老年人群。这种差异归因于年轻埃及患者中遗传性癌症的发病率较高。本研究旨在比较年轻（≤40 岁）和老年（>40 岁）埃及腺癌患者的家族史标准和肿瘤病理学特征。
这是对我们在 8 年内收集的 313 例连续结肠癌和直肠癌患者（133 例年轻，180 例老年）肿瘤病理学特征的前瞻性分析数据。从 258 例患者（112 例年轻，146 例老年）中获得详细的家族史。
41 名年轻患者和 48 名老年患者报告了癌症家族史，差异无统计学意义。10 名年轻患者（9%）报告一级亲属有结直肠癌家族史（3 例符合阿姆斯特丹标准，7 例符合较宽松标准），与老年组无显著差异。两组肿瘤的病理学特征均类似于散发性而非遗传性癌症，两组在肿瘤位置、分化程度、粘蛋白产生、同时性和异时性结直肠肿瘤或息肉以及大体狭窄或溃疡性肿瘤方面无显著差异。1 名年轻患者和 2 名老年患者发生了结肠外肿瘤。
埃及年轻患者结直肠癌的特征与老年患者无显著差异。尽管埃及年轻患者结直肠癌的发病率较高，但家族史和肿瘤的病理学特征并不支持该年龄段结直肠癌的遗传性起源。
