Semenovich V N, Polotskiĭ Iu E, Daĭter A B
Zh Mikrobiol Epidemiol Immunobiol. 1987 Dec(12):81-7.
In experiments on guinea pigs the pathogenicity of leptospires is manifested by their adhesion to liver cells, colonization of the surface of these cells, accumulation of leptospires in the renal interstice and their colonization of the nephrothelial surface of proximal convoluted tubules in the kidneys, by toxic microcirculatory disturbances, dystrophy and necrosis of nephrothelial cells. Then the primary toxic action of circulating leptospires, microcirculatory disturbances and hemorrhagic syndrome augment during the colonization of the surface of liver cells, accompanied by their dystrophy and dissociation, as well as by jaundice. The accumulation of leptospires in the renal interstice and their subsequent multiplication on the nephrothelium of the proximal convoluted tubules are responsible for the development of interstitial nephritis and necrotic nephrosis. The persistence of lesions in the liver and kidneys, occurring in some cases in spite of elimination of the infective agent from these organs due to increasing antibody production suggests the toxic action of immune complexes.
在豚鼠实验中，钩端螺旋体的致病性表现为：它们黏附于肝细胞，在这些细胞表面定植，在肾间质中积聚以及在肾脏近端曲管的肾上皮表面定植，还表现为毒性微循环障碍、肾上皮细胞营养不良和坏死。然后，循环中的钩端螺旋体的原发性毒性作用、微循环障碍和出血综合征在肝细胞表面定植期间加剧，同时伴有肝细胞营养不良和解离以及黄疸。钩端螺旋体在肾间质中的积聚及其随后在近端曲管肾上皮上的繁殖是间质性肾炎和坏死性肾病发展的原因。尽管由于抗体产生增加而从这些器官中清除了感染因子，但在某些情况下肝脏和肾脏中的病变仍然持续存在，这表明免疫复合物具有毒性作用。
