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The Role of Microbiomes in Pregnant Women and Offspring: Research Progress of Recent Years.微生物群落在孕妇和后代中的作用：近年来的研究进展
Front Pharmacol. 2020 May 8;11:643. doi: 10.3389/fphar.2020.00643. eCollection 2020.
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Women's multisite microbial modulation during pregnancy.女性孕期多部位微生物调节。
Microb Pathog. 2020 Oct;147:104230. doi: 10.1016/j.micpath.2020.104230. Epub 2020 May 16.
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Comparison of Methods To Collect Fecal Samples for Microbiome Studies Using Whole-Genome Shotgun Metagenomic Sequencing.用于宏基因组测序的全基因组 shotgun 微生物组研究的粪便样本采集方法比较。
mSphere. 2020 Feb 26;5(1):e00827-19. doi: 10.1128/mSphere.00827-19.
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Vaginal Microbiome of Pregnant Indian Women: Insights into the Genome of Dominant Lactobacillus Species.印度孕妇的阴道微生物组：优势乳杆菌属物种基因组的研究进展。
Microb Ecol. 2020 Aug;80(2):487-499. doi: 10.1007/s00248-020-01501-0. Epub 2020 Mar 23.
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Vaginal microbiome diversity and preterm birth: results of a nested case-control study in Peru.阴道微生物组多样性与早产：秘鲁嵌套病例对照研究结果。
Ann Epidemiol. 2020 Jan;41:28-34. doi: 10.1016/j.annepidem.2019.11.004. Epub 2019 Dec 5.
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Microbiome Multi-Omics Network Analysis: Statistical Considerations, Limitations, and Opportunities.微生物组多组学网络分析：统计考量、局限性与机遇
Front Genet. 2019 Nov 8;10:995. doi: 10.3389/fgene.2019.00995. eCollection 2019.
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Dynamics of cortical progenitors and production of subcerebral neurons are altered in embryos of a maternal inflammation model for autism.自闭症母体炎症模型胚胎皮质祖细胞动力学和皮质下神经元生成改变。
Mol Psychiatry. 2021 May;26(5):1535-1550. doi: 10.1038/s41380-019-0594-y. Epub 2019 Nov 18.
9
The vaginal microbial communities of healthy expectant Brazilian mothers and its correlation with the newborn's gut colonization.健康巴西孕妇的阴道微生物群落及其与新生儿肠道定植的相关性。
World J Microbiol Biotechnol. 2019 Oct 10;35(10):159. doi: 10.1007/s11274-019-2737-3.
10
Vaginal Microbiome Signature Is Associated With Spontaneous Preterm Delivery.阴道微生物群特征与自发性早产有关。
Front Med (Lausanne). 2019 Sep 10;6:201. doi: 10.3389/fmed.2019.00201. eCollection 2019.

微生物组流行病学评估的见解以及确定微生物组与不良妊娠结局之间关系的挑战。

Insights into epidemiologic assessments of the microbiome and challenges in identifying microbiome relationships with adverse pregnancy outcomes.

作者信息

Blostein Freida, Foxman Betsy

机构信息

University of Michigan School of Public Health, Ann Arbor, MI, 48103.

出版信息

Curr Epidemiol Rep. 2021 Sep;8:143-150. doi: 10.1007/s40471-021-00263-8. Epub 2021 Feb 23.

DOI:10.1007/s40471-021-00263-8
PMID:34458070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8386496/
Abstract

PURPOSE OF REVIEW

We describe different methods for microbiome assessment and analysis and highlight some of the challenges of using omics data in epidemiologic studies of adverse pregnancy outcomes.

RECENT FINDINGS

Human microbiomes are dynamic and vary by ancestry and geography. The composition and dynamics of the vaginal microbiome has been associated with risk of preterm birth.

SUMMARY

There are several different methods for characterizing the microbiome. Choice of method depends on the research question and resources available. Added to known challenges of conducting and analyzing epidemiologic studies are the unique challenges associated with microbiome detection and analysis. The resulting omics assessments of human microbial communities have great potential to identify prognostics, diagnostics and potentially therapeutics for adverse pregnancy outcomes.

摘要

综述目的

我们描述了微生物组评估和分析的不同方法，并强调了在不良妊娠结局的流行病学研究中使用组学数据所面临的一些挑战。

最新发现

人类微生物组是动态的，因血统和地理位置而异。阴道微生物组的组成和动态变化与早产风险相关。

总结

有几种不同的方法来表征微生物组。方法的选择取决于研究问题和可用资源。除了进行和分析流行病学研究的已知挑战外，微生物组检测和分析还存在独特的挑战。由此产生的对人类微生物群落的组学评估在识别不良妊娠结局的预后、诊断和潜在治疗方法方面具有巨大潜力。