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线索诱导大鼠赌博任务。

Cued Rat Gambling Task.

作者信息

Barrus Michael M, Winstanley Catharine A

机构信息

Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Bio Protoc. 2017 Feb 5;7(3):e2118. doi: 10.21769/BioProtoc.2118.

DOI:10.21769/BioProtoc.2118
PMID:34458443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8376599/
Abstract

The ability of salient cues to serve as powerful motivators has long been recognized in models of drug addiction, but little has been done to investigate their effects on complex decision making. The Cued rat Gambling Task (CrGT) is an operant behavioural task which pairs salient, audiovisual cues with the delivery of sucrose pellet rewards on complex schedules of reinforcement that involve both sugar pellet 'wins' and timeout penalty 'losses'. The task was designed with the intention of providing insight into the influence of such cues on decision making in a manner that models human gambling.

摘要

显著线索作为强大动机的能力在药物成瘾模型中早已得到认可,但在研究它们对复杂决策的影响方面却做得很少。线索提示大鼠赌博任务(CrGT)是一种操作性行为任务,它将显著的视听线索与蔗糖颗粒奖励的发放配对,采用复杂的强化时间表,其中包括糖颗粒“赢”和超时惩罚“输”。设计该任务的目的是以模拟人类赌博的方式深入了解此类线索对决策的影响。

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本文引用的文献

1
Dopamine D3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task.多巴胺D3受体调节赢牌配对线索在大鼠赌博任务中增加风险选择的能力。
J Neurosci. 2016 Jan 20;36(3):785-94. doi: 10.1523/JNEUROSCI.2225-15.2016.
2
Disadvantageous decision-making on a rodent gambling task is associated with increased motor impulsivity in a population of male rats.在一项啮齿动物赌博任务中做出不利决策与雄性大鼠群体中运动冲动性增加有关。
J Psychiatry Neurosci. 2015 Mar;40(2):108-17. doi: 10.1503/jpn.140045.
3
Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task.丘脑底核深部脑刺激增加大鼠赌博任务中的过早反应。
Behav Brain Res. 2013 May 15;245:76-82. doi: 10.1016/j.bbr.2013.02.011. Epub 2013 Feb 19.
4
Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task.同时阻断多巴胺和去甲肾上腺素再摄取可促进大鼠赌博任务中的不利决策。
Psychopharmacology (Berl). 2013 Feb;225(3):719-31. doi: 10.1007/s00213-012-2857-z. Epub 2012 Sep 12.
5
Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task.使用新型大鼠赌博任务评估5-羟色胺能和多巴胺能对赌博行为的调节作用。
Neuropsychopharmacology. 2009 Sep;34(10):2329-43. doi: 10.1038/npp.2009.62. Epub 2009 Jun 17.