Yamamoto N, Yanagi K, Matuyama H, Shimizu K, Mitsui H, Shimabukuro T, Yamamoto M, Sakatoku J, Fujita T, Matsuoka K
Department of Pharmacology, School of Medicine, Yamaguchi University.
Hinyokika Kiyo. 1987 Nov;33(11):1760-5.
Three cases of urogenital malignancy were treated with 80-120/m2 of cisplatin by a 0.5-hour (rapid) or 4-hour (slow) infusion. Each patient received three courses of repeated chemotherapy. The kinetics of total platinum was measured up to 48 hours in the blood and urine. The blood peak concentrations were achieved 6.0 micrograms/ml by rapid infusion, 2.0 micrograms/ml by slow infusion. The time dependent urinary excretion rate against total administered dose was 40% in 60 min. by rapid infusion, 20% in 16 hours by slow infusion. The volume of distribution correlated with infusion time. Rapid infusion way of cisplatin could be better to treat the patient with bulky tumor mass or patients with uroepithelial cancer like CIS, because a higher blood and urine concentration can be obtained than by slow infusion.
三例泌尿生殖系统恶性肿瘤患者接受了顺铂治疗，剂量为80 - 120/m²，通过0.5小时（快速）或4小时（缓慢）静脉输注。每位患者接受三个疗程的重复化疗。在血液和尿液中测量总铂的动力学直至48小时。快速输注时血液峰值浓度达到6.0微克/毫升，缓慢输注时为2.0微克/毫升。相对于总给药剂量，快速输注在60分钟内尿排泄率为40%，缓慢输注在16小时内为20%。分布容积与输注时间相关。顺铂快速输注方式可能更适合治疗肿瘤体积较大的患者或患有CIS等尿路上皮癌的患者，因为与缓慢输注相比，可获得更高的血液和尿液浓度。
