DeGregorio M, Wilbur B, King O, Wallenberg J, Prewitt S, Phillips J, Wilbur J
Cancer Treat Rep. 1986 Dec;70(12):1437-8.
Peak CSF and serum platinum levels were examined in a patient with ependymoma after each of four consecutive cisplatin doses of 100 mg/m2 administered by either 30-minute or 3-hour infusion. Both infusion lengths produced similar peak CSF platinum levels within 2 hours after the completion. Ultrafiltrate serum platinum levels correlated with the CSF platinum levels, whereas total plasma platinum did not. No differences in clinical toxicity or response were seen between the two methods of administration. Based on these preliminary results, similar peak CSF platinum concentrations are achieved by 30-minute or 3-hour infusions, and ultrafiltrate serum platinum concentrations can be used to predict these levels.
在一名室管膜瘤患者中，通过30分钟或3小时输注连续给予四次100mg/m²顺铂剂量后，检测了脑脊液（CSF）和血清铂的峰值水平。两种输注时长在输注结束后2小时内产生的CSF铂峰值水平相似。超滤血清铂水平与CSF铂水平相关，而总血浆铂则不然。两种给药方法在临床毒性或反应方面未见差异。基于这些初步结果，30分钟或3小时输注可达到相似的CSF铂峰值浓度，并且超滤血清铂浓度可用于预测这些水平。
