含炔基天然产物的生物合成。
Biosynthesis of alkyne-containing natural products.
作者信息
Li Xinyang, Lv Jian-Ming, Hu Dan, Abe Ikuro
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University Guangzhou 510632 People's Republic of China.
出版信息
RSC Chem Biol. 2020 Dec 21;2(1):166-180. doi: 10.1039/d0cb00190b. eCollection 2021 Feb 1.
Alkyne-containing natural products are important molecules that are widely distributed in microbes and plants. Inspired by the advantages of acetylenic products used in the fields of medicinal chemistry, organic synthesis and material science, great efforts have focused on discovering the biosynthetic enzymes and pathways for alkyne formation. Here, we summarize the biosyntheses of alkyne-containing natural products and introduce biosynthetic strategies for alkyne-tagged compound production.
含炔基的天然产物是广泛分布于微生物和植物中的重要分子。受炔类产物在药物化学、有机合成和材料科学领域应用优势的启发，人们致力于发现形成炔基的生物合成酶和途径。在此，我们总结含炔基天然产物的生物合成，并介绍生产炔基标记化合物的生物合成策略。
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