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乳腺癌组织病理学、分类及临床管理:当前观点

Breast cancer histopathology, classification and clinical management: Current perspectives.

作者信息

Waykar Ravindra, Kumarapillai Srinivasakumar

机构信息

Department of Pharmacy, Lincoln University College, Wisma Lincoln, Jalan SS 6/12, 47301 Petaling Jaya, Selangor Darul Ehsan, Malaysia.

出版信息

Bioinformation. 2024 Dec 31;20(12):2069-2079. doi: 10.6026/9732063002002069. eCollection 2024.

Abstract

Breast cancer (BC) manifests as a diverse group of malignancies and presents as a wide array of tumors with distinct morphological, biological and clinical characteristics. Molecular classification of BC serves as the basis for current precision-oriented therapeutic strategies. Upcoming therapeutic strategies will emphasize personalized medicine and tailoring treatments according to each patient's specific needs. These approaches will involve modulating the therapy intensity based on the biological characteristics of tumours and early predictive indicators, allowing for more precise and adaptable care in oncology. Additionally, there remains an unfulfilled requirement for the creation of new medications to treat breast cancer in its early stages, as well as in advanced cases. This review article presents an extensive examination of breast cancer, delving into its prevalence, contributing factors, molecular and cellular features and therapeutic interventions.

摘要

乳腺癌(BC)表现为多种恶性肿瘤,呈现出具有不同形态、生物学和临床特征的广泛肿瘤类型。乳腺癌的分子分类是当前以精准为导向的治疗策略的基础。即将到来的治疗策略将强调个性化医疗,并根据每位患者的特定需求定制治疗方案。这些方法将涉及根据肿瘤的生物学特征和早期预测指标来调整治疗强度,从而在肿瘤学中实现更精确、更具适应性的护理。此外,对于开发用于治疗早期以及晚期乳腺癌的新药物,仍存在未满足的需求。这篇综述文章对乳腺癌进行了广泛研究,深入探讨了其患病率、促成因素、分子和细胞特征以及治疗干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6861/11993385/503e2baf5bb1/9732063002002069F1.jpg

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