Hartescu Iuliana, Stensel David J, Thackray Alice E, King James A, Dorling James L, Rogers Eva N, Hall Andrew P, Brady Emer M, Davies Melanie J, Yates Thomas, Morgan Kevin
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
National Institute for Health Research (NIHR), Leicester Biomedical Research Centre, Leicester, UK.
J Sleep Res. 2022 Apr;31(2):e13469. doi: 10.1111/jsr.13469. Epub 2021 Aug 29.
While limited evidence suggests that longer sleep durations can improve metabolic health in habitual short sleepers, there is no consensus on how sustained sleep extension can be achieved. A total of 18 men (mean [SD] age 41 [ 9] years), who were overweight/obese (mean [SD] body mass index 30 [3] kg/m ) and short sleepers at increased risk of type 2 diabetes were randomised to a 6-week sleep-extension programme based on cognitive behavioural principles (n = 10) or a control (n = 8) group. The primary outcome was 6-week change in actigraphic total sleep time (TST). Fasting plasma insulin, insulin resistance (Homeostatic Model Assessment for Insulin Resistance [HOMA-IR]), blood pressure, appetite-related hormones from a mixed-meal tolerance test, and continuous glucose levels were also measured. Baseline to 6-week change in TST was greater in the sleep-extension group, at 79 (95% confidence interval [CI] 68.90, 88.05) versus 6 (95% CI -4.43, 16.99) min. Change in the sleep-extension and control groups respectively also showed: lower fasting insulin (-11.03 [95% CI -22.70, 0.65] versus 7.07 [95% CI -4.60, 18.74] pmol/L); lower systolic (-11.09 [95% CI -17.49, -4.69] versus 0.76 [95% CI -5.64, 7.15] mmHg) and diastolic blood pressure (-12.16 [95% CI -17.74, -6.59] versus 1.38 [95% CI -4.19, 6.96] mmHg); lower mean amplitude of glucose excursions (0.34 [95% CI -0.57, -0.12] versus 0.05 [95% CI -0.20, 0.30] mmol/L); lower fasting peptide YY levels (-18.25 [95%CI -41.90, 5.41] versus 21.88 [95% CI -1.78, 45.53] pg/ml), and improved HOMA-IR (-0.51 [95% CI -0.98, -0.03] versus 0.28 [95% CI -0.20, 0.76]). Our protocol increased TST and improved markers of metabolic health in male overweight/obese short sleepers.
虽然有限的证据表明，延长睡眠时间可以改善习惯性短睡眠者的代谢健康，但对于如何实现持续的睡眠延长尚无共识。共有18名男性（平均[标准差]年龄41[9]岁），他们超重/肥胖（平均[标准差]体重指数30[3]kg/m²）且为短睡眠者，患2型糖尿病的风险增加，被随机分为基于认知行为原则的6周睡眠延长计划组（n = 10）或对照组（n = 8）。主要结局是6周内活动记录仪记录的总睡眠时间（TST）的变化。还测量了空腹血浆胰岛素、胰岛素抵抗（胰岛素抵抗稳态模型评估[HOMA-IR]）、血压、混合餐耐量试验中的食欲相关激素以及连续血糖水平。睡眠延长组TST从基线到6周的变化更大，为79（95%置信区间[CI]68.90，88.05）分钟，而对照组为6（95%CI -4.43，16.99）分钟。睡眠延长组和对照组的变化还分别显示：空腹胰岛素水平降低（-11.03[95%CI -22.70，0.65]对7.07[95%CI -4.60，18.74]pmol/L）；收缩压降低（-11.09[95%CI -17.49，-4.69]对0.76[95%CI -5.64，7.15]mmHg）和舒张压降低（-12.16[95%CI -17.74，-6.59]对1.38[95%CI -4.19，6.96]mmHg）；葡萄糖波动平均幅度降低（0.34[95%CI -0.57，-0.12]对0.05[95%CI -0.20，0.30]mmol/L）；空腹肽YY水平降低（-18.25[95%CI -41.90，5.41]对21.88[95%CI -1.78，45.53]pg/ml），以及HOMA-IR改善（-0.51[95%CI -0.98，-0.03]对0.28[95%CI -0.20，0.76]）。我们的方案增加了男性超重/肥胖短睡眠者的TST并改善了代谢健康指标。
